Product ID:HIPPURAN I 131 INJECTION
MSDS Date:01/01/1992
FSC:6505
NIIN:00N040073
MSDS Number: BRMYN

MALLINCKRODT

2703 WAGNER PL
MARYLAND HEIGHTS, MO 63043
US

Emergency Phone: 314-344-3800

Info Phone: 314-344-3800

Cage: ZA916

MALLINCKRODT MEDICAL, INC

M MARYLAND HEIGHTS, MO 63043 US

Telephone: 314-770-7800

Cage: ZA916

HIPPURIC ACID, O-IODO-MONOSODIUM SALT; (HIPPURAN I-131, MFR

CAS: 133-17-5

RTECS: MR8162000

Fraction By Weight: <1%

ACETIC ACID, (ETHYLENEDINITRILO)TETRA-, DISODIUM SALT;

CAS: 139-33-3

RTECS: AH4375000

Fraction By Weight: 0.005%

CITRIC ACID, TRISODIUM SALT; (SODIUM CITRATE)

CAS: 68-04-2

RTECS: GE8300000

Fraction By Weight: 0.02%

BENZOIC ACID, P-HYDROXY-, PROPYL ESTER; (PROPYLPARABEN)

CAS: 94-13-3

RTECS: DH2800000

Fraction By Weight: 0.03%

BENZOIC ACID, P-HYDROXY-, METHYL ESTER; (METHYLPARABEN)

CAS: 99-76-3

RTECS: DH2450000

Fraction By Weight: 0.1%

1,2-PROPANEDIOL; (PROPYLENE GLYCOL)

CAS: 57-55-6

RTECS: TY2000000

Fraction By Weight: 37.5%

I-131 BY THYROID CAN RESULT IN SLIGHT TO

RTECS: 9999999ZZ

WASH W/WATER FOR @ LST 15 MINS/UNTIL NO

RTECS: 9999999ZZ

ARE HNDLD/STORED. READ PACKAGE INSERT PRIOR TO

RTECS: 9999999ZZ

IN CONFORMITY W/REGS APPROP TO GOVT AGENCY AUTH TO

RTECS: 9999999ZZ

BE KEPT W/IN ITS CNTNR OR W/IN HVR SHIELDING. AVOID

RTECS: 9999999ZZ

EXPOSURE TO RADIATION.

RTECS: 9999999ZZ

LD50 LC50 Mixture:NONE SPECIFIED BY MANUFACTURER.
Routes of Entry: Inhalation:NO Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:HAZ, NON-RADIOACTIVE INGS FOUND IN
HIPPURAN ARE SKIN & EYE IRRITS, BUT DUE TO SM QTYS PRESENT IN EACH
CNTNR, NO ADVERSE HLTH EFTS ARE EXPECTED TO OCCUR. ACUTE:INHAL:VERY
SM FRACTION OF HIPPURAN COULD BREAK DOWN & EMIT RADIOACTIVE FUMES
CNTNG I-131. NOT EXPECTED TO BE HLTH HAZ VIA INHAL. INGEST:MAY
(EFTS OF OVEREXP)
Explanation of Carcinogenicity:NOT RELEVANT
Effects of Overexposure:HLTH HAZ:CAUSE ASYMPTOMATIC PHYSIOLOGICAL
UPTAKE BY THYROID GLAND/OTHER TISS. SKIN:NOT EXPECTED TO PRDCE ANY
ACUTE ADVERSE HLTH EFTS. EYE:NO ADVERSE EFT EXPECTED, BUT MAY CAUSE
MECH IRRIT. CHRONIC:HLT H RISKS ASSOC W/CHRONIC RADIA EXPOS
(CANCER, LEUKEMIA, GENETIC & TERATOGENIC EFTS) ARE BELIEVED TO
INVOLVE (SUPDAT)
Medical Cond Aggravated by Exposure:NO INFORMATION FOUND.

First Aid:INHAL:REMOVE TO FRESH AIR. SUPPORT BRTHG (GIVE O*2/ARTF RESP)
. INGEST:NOTIFY RADIA SAFETY PERS IMMED. AMT OF I-131 IN THYROID
GLAND SHLD BE ASSESSED & DOCUMENTED. THYROID BLOCKING AGENT MAY BE
WARRANTED & ADMIN UNDER DIRECTION OF MD. SKIN:WASH AFFECTED AREA
THORO W/SOAP & WATER UNTIL NO MORE RADIOACTIVITY CAN BE REMOVED.
ALWAYS BLOT DRY. DO NOT ABRADE SKIN. NOTIFY RADIA SAFETY PERS. (ING
8)

Extinguishing Media:USE ANY MEANS SUITABLE FOR EXTINGUISHING
SURROUNDING FIRE.
Fire Fighting Procedures:WEAR NIOSH/MSHA APPROVED SCBA & FULL
PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:NOT CONSIDERED TO BE A FIRE OR EXPLOSION
HAZARD.

Spill Release Procedures:IF PROD IS RECEIVED IN LEAKING CNDTN/ANY
LOSS/RELS OF RADIOACTIVE CONTENTS OCCUR, NOTIFY YOUR RADIA SAFETY
DEPT & MFR AT 314-344-3800. ALL CLEANUP OPERATIONS SHLD BE
PERFORMED ACCORDING TO STD OPERATI NG PROCS (SOPS) ESTABLISHED FOR
YOUR FACILITY.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

Handling and Storage Precautions:STORE AT 15C-30C. HNDLG TIME SHLD BE
KEPT TO MIN & APPROP SHIELDING SHLD BE USED. HNDLG DEVICES SUCH AS
SYRINGE SHIELDS & TONGS SHLD BE USED.
Other Precautions:STOR & DISP OF PROD SHLD BE CONTROLLED IN MANNER
WHICH IS IN COMPLIANCE W/APPROP REGS OF FED/STATE GOVT AGENCY AUTH
TO LICENSE USE OF THIS RADIONUCLIDE. NO SMOKING, EATING/DRINKING
SHLD BE ALLOWED IN ANY AREA WHERE RADIOACTIVE MATLS (ING 9)

Respiratory Protection:USE NIOSH/MSHA APPROVED RESPIRATOR APPROPRIATE
FOR EXPOSURE OF CONCERN . NOT EXPECTED TO REQUIRE PERSONAL
RESPIRATOR USAGE.
Ventilation:PROPERLY SEALED CONTAINERS ARE NOT EXPECTED TO REQUIRE ANY
SPECIAL VENTILATION.
Protective Gloves:DISPOSABLE PLASTIC/LATEX/RUBBER GLOVES.
Eye Protection:CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:LABCOAT.
Work Hygienic Practices:REMOVE PROMPTLY ANY CONTAMINATION FROM SKIN,
EYES OR CLOTHING.
Supplemental Safety and Health
EFTS OF OVEREXP:LEVELS OF RADIA EXPOS WHICH ARE MUCH HIGHER THAN THOSE
PERMITTED OCCUPATIONALLY. TOX DATA:IT IS WIDELY ACCEPTED BY THE
SCIENTIFIC COMMUNITY THAT EXPOS TO SUFFICIENT QTYS OF IONIZING RA
DIA CAN POTNTLY CAUSE HARMFUL BIOLOGICAL EFTS WHICH INCL CANCER,
LEUKEMIA & GENETIC TERATOGENIC EFTS. UPTAKE OF (ING 7)

Boiling Pt:B.P. Text:212F,100C
Melt/Freeze Pt:M.P/F.P Text:32F,0C
Solubility in Water:SOLUBLE
Appearance and Odor:CLEAR, COLORLESS LIQUID IN 10 ML GLASS VIAL;
ODORLESS.

Stability Indicator/Materials to Avoid:YES
NO INFORMATION FOUND.
Stability Condition to Avoid:NONE SPECIFIED BY MANUFACTURER.
Hazardous Decomposition Products:MAY EMIT RADIOACTIVE FUMES CONTAINING
I-131 WHEN HEATED TO DECOMPOSITION.

Waste Disposal Methods:RADIOACTIVE WASTE SHOULD BE DISPOSED OF
ACCORDING TO SOPS ESTABLISHED BY YOUR RADIATION SAFETY OFFICER.
ENSURE COMPLIANCE W/LOCAL, STATE & FEDERAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.