Product ID:LINCOCIN STERILE SOLUTION, 43507
MSDS Date:06/30/1994
FSC:6505
NIIN:00-481-1750
MSDS Number: BXFQS

UPJOHN CO

7171 PORTAGE RD
KALAMAZOO, MI 49001-0199
US

Emergency Phone: 616-323-5122

Info Phone: 616-323-7555

Cage: EO390

UPJOHN CO

KALAMAZOO, MI 49001 US

Telephone: 30 PM)

Cage: EO390

WATER

CAS: 7732-18-5

RTECS: ZC0110000

Fraction By Weight: 70-100%

OSHA PEL N/K

ACGIH TLV: N/K

D-ERYTHRO-D-GALACTO-OCTOPYRANOSIDE,METHYL 6,8-

CAS: 859-18-7

RTECS: RH6315000

Fraction By Weight: 30%

OSHA PEL N/K

ACGIH TLV: N/K

THIO-, MONOHYDROCHLORIDE, TRANS-ALPHA-; (LINCOMYCIN

RTECS: 9999999ZZ

NON-HAZARDOUS INGREDIENTS

Fraction By Weight: <10%

OSHA PEL N/K

ACGIH TLV: N/K

BASIC PHS AT ELEVATED TEMPS. LINCOMYCIN CAN BE

RTECS: 9999999ZZ

& SO, IS EXPECTED TO BE RELATIVELY MOBILE & MIGRATE

RTECS: 9999999ZZ

PROD CAN UNDERGO HYDROLYSIS AT BOTH ACID & BASIC PHS

RTECS: 9999999ZZ

DEGRADATION IS SM. LINCOMYCIN BIOACTIVITY IS READILY

RTECS: 9999999ZZ

DEGRADATION WAS ABOUT 20 DAYS. BIOACCUM

RTECS: 9999999ZZ

ALL PHS. OCTANOL-WATER PARTITION AT PH 7 IS 2.55.

RTECS: 9999999ZZ

9.96 RESPECTIVELY. LINCOMYCIN WILL BE EXPECTED TO

RTECS: 9999999ZZ

PROD WILL HAVE

RTECS: 9999999ZZ

MICROORGANISMS UNTIL IT IS DEGRADED. SM AMTS SENT TO

RTECS: 9999999ZZ

FLORA OF SEWAGE TREATMENT FACILITIES.

RTECS: 9999999ZZ

LD50 LC50 Mixture:LD50(ORAL,RAT):15,645 MG/KG.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:PROD IS NOT ACUTELY TOX, BUT MAY CAUSE
IRRIT TO EYES, SKIN & RESP PASSAGES. RPTD EXPOS MAY CAUSE NAUS,
ABDOM CRAMPS, DIARR & COLITIS, WHICH MAY BEGIN SEVERAL WEEKS AFTER
EXPOS HAS CEASED. SOME HEMATOP OITIC EFTS HAVE BEEN REPORTD W/USE
OF LINCOMYCIN HYDROCHLORIDE. HYPERSENSIT RXNS HAVE BEEN REPORTED
(EFTS OF OVEREXP)
Explanation of Carcinogenicity:NOT RELEVANT
Effects of Overexposure:HLTH HAZS:IN PEOPLE KNOWN TO BE SENSITIVE TO
PENICILLIN. TOX INFO:ACUTE:SENSIT:HYPERSENSIT RXNS TO PROD HAVE
BEEN REPORTED. THESE RXNS WERE CHARACTERIZED BY ANGIONEUROTIC
EDEMA, SERUM SICKNESS & ANAPH YLAXIS & OCCURED OCCAS TO PEOPLE
KNOWN TO BE SENSITIVE TO PENICILLIN. RARE INSTANCES OF ERYTHEMA
MULTIFORME, (SUP DAT)
Medical Cond Aggravated by Exposure:EXPOS TO PROD IS CONTRAINDICATED IN
PEOPLE W/HISTORY OF HYPERSENSIT TO LINCOMYCIN, CLINDAMYCIN/RELATED
ANTIBIOTICS, HISTORY OF ASTHMA/SIGNIFICANT ALLERGIES/HISTORY OF GI
DISEASE (ESP COLITIS).

First Aid:EYES:FLUSH WITH WATER FOR AT LEAST 15 MINUTES. HOLD EYELIDS
OPEN TO ASSURE COMPLETE CONTACT WITH WATER. SKIN:WASH WITH SOAP AND
WATER. REMOVE CONTAMINATED CLOTHING. INHALATION:REMOVE FROM
EXPOSURE. IN GESTION:CONTACT A PHYSICIAN OR POISON CONTROL CENTER.

Flash Point:NONFLAMMABLE
Extinguishing Media:WATER, CARBON DIOXIDE OR DRY CHEMICAL.
Fire Fighting Procedures:WEAR NIOSH/MSHA APPROVED SCBA & FULL
PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:NONE KNOWN. HAZARDOUS COMBUSTION
PRODUCTS:CARBON MONOXIDE. CARBON DIOXIDE. NITROGEN OXIDES. SULFUR
OXIDES. HYDROCHLORIC ACID.

Spill Release Procedures:PROVIDE VENT & RESP, SKIN & EYE PROT TO PVNT
OVEREXP. KEEP PROD OUT OF DRAINS; PVNT ENTRY TO SURF WATER,
GROUNDWATER & SOIL. SM SPILLS SHOULD BE ABSORBED W/PAPER
TOWEL/OTHER APPROP MEDIA. LG SPILLS SH OULD BE VACUUMED/SCOOPED &
PLACED IN (SUP DAT)
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

Handling and Storage Precautions:AVOID CONTACT WITH SKIN, EYES AND
CLOTHING. STORE IN A COOL, DRY PLACE AND PROTECT FROM LIGHT. KEEP
OUT OF THE REACH OF CHILDREN.
Other Precautions:NONE SPECIFIED BY MANUFACTURER.

Respiratory Protection:USE NIOSH/MSHA APPROVED RESPIRATOR APPROPRIATE
FOR EXPOSURE OF CONCERN . NOT REQUIRED.
Ventilation:LOCAL EXHAUST.
Protective Gloves:IMPERVIOUS GLOVES .
Eye Protection:ANSI APPROVED CHEM WORKERS GOGGS .
Other Protective Equipment:NONE SPECIFIED BY MANUFACTURER.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING. LAUNDER
CONTAMINATED CLOTHES BEFORE REUSE.
Supplemental Safety and Health
EFTS OF OVEREXP:SOMETIMES RESEMBLING STEVENS-JOHNSON SYNDROME, HAVE
BEEN ASSOC W/PROD. SPILL:SUITABLE CNTNR. ENVIRON FATE:MOBILITY:PROD
MELTS W/DECOMP AT 148C. IT HAS NO MEASUREABLE VP, THEREFORE IT I S
NOT EXPECTED TO ENTER AIR. PROD IS VERY SOL IN WATER (500-1,000
MG/ML) & UNDERGOES HYDROLYSIS AT BOTH ACID & (ING 5)

Solubility in Water:FREELY SOLUBLE
Appearance and Odor:LIQUID (300 MG/ML) IN 2-ML AND 10-ML VIALS.

Stability Indicator/Materials to Avoid:YES
NONE.
Stability Condition to Avoid:NONE.
Hazardous Decomposition Products:NONE.

Waste Disposal Methods:DISPOSE OF BY INCINERATION IN ACCORDANCE WITH
APPLICABLE INTERNATIONAL, NATIONAL, STATE AND/OR LOCAL WASTE
DISPOSAL REGULATIONS.

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This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
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disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
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particular situation.