Product ID:6810-80-8 LOMOTIL TABLETS PN:006131
MSDS Date:05/20/1996
FSC:6505
NIIN:00-118-1914
MSDS Number: CCLNK

G.D. SEARLE

CHICAGO, IL 60680
US

Emergency Phone: 847-982-7000

Info Phone: 847-982-7000

Cage: 04525

G.D. SEARLE

5110 CHICAGO, IL 60680 US

Telephone: 847-982-7000

Cage: 04525

ATROPINE SULFATE

CAS: 55-48-1

RTECS: CK2450000

Fraction By Weight: 0.04%

EXCIPIENTS

Fraction By Weight: 95.96%

DIPHENOXYLATE HYDROCHLORIDE

CAS: 3810-80-8

RTECS: NS5300000

Fraction By Weight: 4%

LD50 LC50 Mixture:ORAL RAT LD50 221MG/KG.
Routes of Entry: Inhalation:NO Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:INHAL/SKIN/EYE:NO INFO.INGEST:SHORT
TERM EXPO:NERVOUS SYS,ALLERGIC,GASTROINTESTINAL SYS,OVERDOSES MAY
RESULT IN ABNORMAL PUPIL SIZE,UNUSUAL EYE MOVEMENTS,BREATHING
DIFFICULTIES,COMA,DEATH.DIPHENOXYLAT E HCL OPIOID,PROUDCE ACUTE
TOXICITY SIMILAR TO THAT OBSERVED W/MORPHINE.OVERDOSAGES RESP
DEPRESS,NAU,VOMIT,DIZZ,(SUPPLE)
Explanation of Carcinogenicity:PER MSDS:CARCINOGEN STATUS:NO INFO
AVAILABLE.
Effects of Overexposure:NERVOUS SYS:NUMBNESS OF
EXTREMITIES,EUPHORIA,DEPRESS,MALAISE/LETHARGY,CONFUSION,SEDATION/DR
OWS,DIZZ,RESTLESSNESS,HEAD.ALELRGIC:SWELLING OF GUMS,ITCHING SKIN
RASH,SHORTNESS OF BREATH.GI SYS:VOMIT,NAU,L OSS OF
APPETITE,ABDOMINAL DISCOMFORT,PANCREATITIS,FEVER,RAPID HEART
BEAT,URINE RETENTION,FLUSING,DRYNES OF SKIN/MUC MEMB
Medical Cond Aggravated by Exposure:AVOID CONTACT IF:PEOPLE
W/ALLERGY/SENS TO DIPHENOXYLATE HCL/ATROPINE SULFATE,PREG/NURSING
FEMALES.PEOPLE W/INTESTINAL DISORDES,ULCERATING COLITIS,LIVER
DISORDERS,TAKING MAO INHIBITOR,TRANQUILZR (SUPP)

First Aid:INHAL:REMOVE TO FRESH AIR,MONITOR BLOOD
PRESSURE,RESP,TEMP,GEN CONDITIONS.GET MED ATTN PROMPTLY.SKIN:REMOVE
CONTAMN CLOTH.WASH W/SOAP/WTAER.IRRIT DEVELOPS GET MED
ATTN.EYE:IMEMD FLUSH W/LG AMTS OF WAT ER FOR @15MINS.GET MED ATTN
PROMPTLY.INGEST:INDUCE VOMIT IF CONSC/CAN SAFETLY VOMIT.PROVIDE GEN
SUPPORT/MONITOR BLOOD PRESSURE/RESP/TEMP/GEN CONDITION.GET MED ATTN
PROMPTLY.DR:OVERDOSE INDUCE (SUPPLE)

Flash Point:NOT PROVIDE
Autoignition Temp:Autoignition Temp Text:NA
Lower Limits:NA
Upper Limits:NA
Extinguishing Media:USE DRY CHEM, CARBON DIOXIDE, WATER SPRAY, REGULAR
FOAM OR EXTINGUISHING AGENT SUITABLE FOR SURROUNDING FIRE.
Fire Fighting Procedures:EVACUATE AREA & FIGHT FIRE FROM SAFE
DISTANCE.AS IN ANY FIRE WEAR PRESSURE DEMAND SELF-CONTAINED
BREATHING APPARATUS & FULL PROTECTIVE GEAR.
Unusual Fire/Explosion Hazard:NONE SPECIFIED BY MANUFACTURER.

Spill Release Procedures:VACUUM MATL W/HIGH EFFICIENCY PARTICULATE AIR
(HEPA) FILTERED VACUUM CLEANER OR WET SWEEP. COLLECT WASTE FOR
PROPER DISPOSAL.KEEP UNNECESSARY PEOPLE AWAY. DO NOT FLUSH SPILLED
MATL INTO SEWER.
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

Handling and Storage Precautions:USE W/ADEQUATE VENTILATION.AVOID
BREATHING DUST.AVOID CONTACT W/EYE/SKIN/CLOTH.NO SPECIAL STORAGE
PROVISIONS NECESSARY.CARE
Other Precautions:GLOVES:CMPD HAS NOT BEEN SPECIFICALLY EVALUATED FOR
GLOVE SUITABILITY. TARGET ORGANS:CENTRAL NERVOUS SYTEM,
GASTROINTESTINAL TRACT.CHRONIC EFFECTS:HI DOSE
EXPO(40-60MG/DAY)RESULT IN MORPHINE-LIKE EFFE CTS INCLUDE
EUPHORIA,PHY DEPENDENCE.

Respiratory Protection:RESP CHOICE VARY DEPENDING ON INDIVIDUAL
CIRCUMST.SPEC APPLICATION SHOULD BE EVALUATED TO DETERMINE IF
FOLLOWING RECOMMENDATIONS APPROPR:HEPA FILT CARTRI W/ADEQ VENTI BUT
W/SOME POT FOR EXPO;SUPP AIR RESP FOR W/O ADEQ VENTI;SCBA
FIRE/LIFE.
Ventilation:LOCAL EXHAUST VENTILATION.
Protective Gloves:CHEM RESISTANT GLOVES.(SEE OTHER PRECAU)
Eye Protection:SAFETY GLASSES.
Other Protective Equipment:LONG SLEEVES (IF POTENTIAL SKIN CONTACT) &
DISPOSABLE COVERALLS.
Work Hygienic Practices:NONE SPECIFIED BY MANUFACTURER.
Supplemental Safety and Health
AGGRAVATE CONDITIONS:OR BARBITURATES SHOULD DISCUSS THIS W/PHYSICIAN
BEF EXPO. HEALTH HAZ:DYSPHORIA,CONSTIPATION,URINARY
RETENTIAON,HYPOTENSION. 1STAID:VOMIT/GASTRIC LAVAGE/MECHAN ASSIT
RESP.SLURRY OF 100G ACTIVATED CHARCOAL ADMIN.RESP DEPRESS FROM
LOMOTIL USE PURE NARCOTIC ANTAGONIST(NALOXONE)0.4-2MG.

HCC:T6
Boiling Pt:B.P. Text:NA
Melt/Freeze Pt:M.P/F.P Text:NA
Decomp Temp:Decomp Text:NP
Vapor Pres:NA
Vapor Density:NA
Spec Gravity:NOT KNOWN
pH:NA
Viscosity:NA
Solubility in Water:NOT KNOWN.
Appearance and Odor:OFF-WHITE CRYSTALLINE POWDER.
Percent Volatiles by Volume:NA
Corrosion Rate:NP

Stability Indicator/Materials to Avoid:YES
NONT KNOWN.
Stability Condition to Avoid:NOT KNOWN.
Hazardous Decomposition Products:OXIDES OF NITROGEN AND SULFUR,
HYDROGEN CHLORIDE.

Waste Disposal Methods:CARE SHOULD BE USED IN HNDLG.INCINERATE IN
APPROVED FACILITY.OBSERVE ALL FED/STATE/LOC REGS WHEN DISPO OF THIS
SUBSTANCE.SARA SEC 313:NA.

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