Product ID:BLENOXANE
MSDS Date:08/01/1987
FSC:6505
NIIN:01-052-4769
MSDS Number: BHCPD

BRISTOL-MYERS US PHARMACEUTICAL & NUTRITIONAL GRUP

2404 PENNSYLVANIA ST
EVANSVILLE, IN 47721-0001
US

Emergency Phone: 812-429-5140

Info Phone: 812-429-5140

Preparer: MEDICAL SERVICES

Cage: 29398

BRISTOL-MYERS US PHARMACEUTICAL & NUTRITIONAL GP.

EVANSVILLE, IN 47721-0001 US

Telephone: 812-429-5644

Cage: 29398

BLEOMYCIN

CAS: 11056-06-7

RTECS: EC5988000

BLEOMYCIN SULFATE

CAS: 9041-93-4

RTECS: EC5991990

MINOR COMPONENTS

LD50 LC50 Mixture:LD50 "IPR" RAT = 143 MG/KG
Routes of Entry: Inhalation:NO Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:YES OSHA:NO
Health Hazards Acute and Chronic:ACUTE- EYES:CONJUNCTIVITIS.
SKIN:ABSORBED THROUGH SKIN IN SIGNIFICANT AMOUNTS.POSSIBLE RASH
UPON CONTACT. INHALATION:NO KNOWN EFFECT.
INJECTION:FEVER,CHILLS,HYPOTENSION,WHEEZING. CHRONIC EFFECTS:POSS
IBLY CARCINOGENIC TO HUMANS.
Explanation of Carcinogenicity:BLEOMYCIN IS POSSIBLY CARCINGENIC TO
HUMANS.
Effects of Overexposure:EYES:CONJUNCTIVITIS. SKIN:RASH. INHALATION:NO
KNOWN EFFECTS. INJECTION:FEVER,CHILLS,HYPOTENSION,WHEEZING.
Medical Cond Aggravated by Exposure:PREGNANT WOMEN OR THOSE WHO ARE
BREAST-FEEDING SHOULD AVOID CONTACT WITH THIS PRODUCT.

First Aid:EYES:WASH WITH LARGE AMOUNTS OF WATER FOR AT LEAST 15
MINUTES.SEE DOCTOR IMMEDIATELY. SKIN:WASH IMMEDIATELY WITH SOAP AND
WATER.DO NOT USE A GERMICIDAL CLEANER. INHALATION/INGESTION:SEE
DOCTOR.

Extinguishing Media:USE CARBON DIOXIDE, FOAM, DRY CHEMICAL, OR WATER
FOG.
Fire Fighting Procedures:NONE. (MATERIAL IS IN GLASS VIALS WHICH ARE
NOT LIKELY TO BURN).
Unusual Fire/Explosion Hazard:AVOID INHALATION AND SKIN CONTACT. DO NOT
GET IN EYES.

Spill Release Procedures:WIPE LIQUID WITH ABSORBENT GAUZE. WIPE SOLID
WITH WET ABSORBENT GAUZE. CLEAN,USING BLEACH (PREFERRED) OR
DETERGENT AND WATER.
Neutralizing Agent:5.25% SOD.HYPOCHLORITE OR 1% POT.PERMANGANATE
SOLN.DEACTIVATES BLENOXANE.

Handling and Storage Precautions:SHOULD BE STORED UNDER REFRIGERATION
AT 36-46F (2-8 C). DO NOT STORE NEAR FOOD.
Other Precautions:NONE.

Respiratory Protection:NIOSH-APPROVED DUST RESPIRATOR WITH HIGH
EFFICIENCY DUST FILTER OR POWERED AIR-PURIFYING RESPIRATOR IF
BIOLOGICAL SAFETY CABINET, OR SUITABLE VENTILATION IS NOT
AVAILABLE.
Ventilation:USE BIOLOGICAL SAFETY CABINET FOR PREPARATION, OR AS
DETERMINED BY INDUSTRIAL HYGIENIST.
Protective Gloves:DISPOSABLE SURGICAL LATEX GLOVES.
Eye Protection:PLASTIC FACE SHIELD OR SPLASH GOGGLES.
Other Protective Equipment:PROTECTIVE DISPOSABLE GOWN OF LOW
PERMEABILITY FABRIC WITH CLOSED FRONT,LONG SLEEVES AND ELASTIC
CUFFS.
Work Hygienic Practices:WASH THOROUGHLY BEFORE EATING OR
SMOKING.EATING,DRINKING,SMOKING CHEWING GUM,APPLYING COSMETIC NEAR
PRODUCT IS FORBIDDEN
Supplemental Safety and Health
DISPOSABLE GLOVES SHOULD BE CHANGED EVERY 30 MINUTES AND REMOVED
IMMEDIATELY AFTER OVERT CONTAMINATION. PRE-EMPLOYMENT PHYSICAL
EXAMINATION IS RECOMMENDED.A COMPLETE BLOOD COUNT SHOULD BE
TAKEN.PERIOD IC FOLLOW-UP EXAMINATIONS SHOULD BE DONE AT LEAST
ANNUALLY.MAINTAIN A REGISTRY OF PERSONNEL HANDLING BLENOXANE.

HCC:T6
Solubility in Water:VERY SOLUBLE
Appearance and Odor:COLORLESS TO YELLOWISH POWDER.(MAY TURN BLUE). NO
ODOR.

Stability Indicator/Materials to Avoid:YES
NONE.
Hazardous Decomposition Products:NONE KNOWN.

Waste Disposal Methods:TREAT PRODUCT AND CONTAMINATED MATERIALS AS
HAZARDOUS WASTE.INCINERATION IS RECOMMENDED. DISPOSE OF IN
ACCORDANCE TO FEDERAL,STATE AND LOCAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.