Product ID:RENOGRAFIN 76
MSDS Date:02/19/1993
FSC:6505
NIIN:00-159-5008
MSDS Number: BXBYX

BRSITOL-MYERS SQUIBB,PHARMACEUTICAL GROUP

RT 206 AND PROVIDENCE LINE RD
NEW BRUNSWICK, NJ 08903
US

Emergency Phone: 908-519-2385(DR.HAYES)/800-424-9300

Info Phone: 800-631-5244

Cage: KO157

SQUIBB E R AND SONS INC, WORLD HQ

5250 PRINCETON, NJ 08543-5250 US

Telephone: 800-631-5244

Cage: 78473

DIATRIZOATE MEGLUMINE

Fraction By Weight: 66%

DIATRIZOATE SODIUM

Fraction By Weight: 10%

WATER

CAS: 7732-18-5

RTECS: ZC0110000

Fraction By Weight: >1%

EDETATE DISODIUM

Fraction By Weight: SEE #7%

SODIUM CITRATE (CAS# NOT GIVEN BY MSDS)

Fraction By Weight: SEE #7%

SODIUM HYDROXIDE (SARA III)

CAS: 1310-73-2

RTECS: WB4900000

Fraction By Weight: SEE #7%

OSHA PEL 2 MG/M3

ACGIH TLV: C 2 MG/M3; 9394

EPA Report Quantity: 1000 LBS

DOT Report Quantity: 1000 LBS

INGREDS #4-6 PRESENT @<1% OR USED FOR PH ADJUSTMENT.

RTECS: 9999999ZZ

Fraction By Weight: <1%

LD50 LC50 Mixture:NONE ESTABLISHED
Routes of Entry: Inhalation:NO Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ORAL:MILD/TRANSITORY EFFECTS.LG AMTS
OF CERTAIN MEGLUMINE SALTS MAY RESULT IN NAU,VOMIT,&/OR
DIARR,DEHYDRATION,ELECTROLYTE DISTURB,OCCASSIONALLY
HYPERSENS(ALLERGIC)RX,HYPERTHYROIDISM.INHAL:NOT A HAZ.S KIN/EYE:NO
INFO.HAS PRODUCED HYPERSENS OR ANAPHYLACTOID RXS MANIFESTED BY
EDEMA OF FACE/GLOTTIS,RESP DISTRESS,(SUPPLEME)
Explanation of Carcinogenicity:PER MSDS:CARCINOGEN
LISTS:IARC/NTP/OSHA:NO.
Effects of Overexposure:NAUSEA, VOMITING, DIARR, DEHYDRATION,
ELECTROLYTE DISTURBANCES, HYPERSENSITIVITY RX, HYPERTHYROIDISM,
ANAPHYLACTOID RXS MANIFESTED BY EDEMA OF FACE/GLOTTIS, RESP
DISTRESS, CONVULSIONS, SHOCK.
Medical Cond Aggravated by Exposure:SENS TO IODINE.PERSONAL/FAMILY
HISTORY OF BRONCHIAL ASTHMA,SIGN ALLERGIES,PREVIOUS RXS TO CONTRAST
AGENTS.WHEN GIVEN IN LG VOL FOR DIAG PROCEDURES MULTIPLE
MYELOMA,PHEOCHROMOCYTOMA,SICKLE CELL AGGRAVT

First Aid:EYE:FLUSH W/LG AMTS OF WATER FOR 15-20MINS. SKIN:WASH W/SOAP
& WATER. GET MED ATTN IF IRRIT DEVELOPS/PERSISTS. INGEST:GET MED
ATTN IMMED. INHAL:REMOVE TO FRESH AIR. IF DIFFICULTY IN BREATHING
ADMINIST ER OXYGEN. IF NOT BREATHING ARTIFICIAL RESPIRATION CAN BE
ATTEMPTED. GET MED ATTN IMMED.

Flash Point:NOT AVAILABLE
Lower Limits:N/AVAILABLE
Upper Limits:N/AVAILABLE
Extinguishing Media:USE WATER.
Fire Fighting Procedures:AS W/ALL FIRES REMOVE PEOPLE TO SAFE AREA.WHEN
MATL INVOLVE IN FIRE SCBA & FULL PROTECTIVE CLOTHING SHOULE BE WORN
BY FIREFIGHTERS.COOL FIRE-EXPO CNTNRS (SUPPL)
Unusual Fire/Explosion Hazard:NONE SPECIFIED BY MANUFACTURER.

Spill Release Procedures:WEAR SUITABLE PROT CLOTH.ABSORB LIQ
W/APPROPRIATE ABSORBENT MATL.PLACE INTO APPROPRIATE CNTNR FOR
DISPOSAL.LATEX GLOVE/EYE PROT SHOULD BE WORN AS MIN PRECAUTION.ADDN
PROT CLOTH/EQPMT NEEDED DEPENDING ON EXTENT OF
SPILL.VENTILATE/DECONTAMINAFT REMOVE
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

Handling and Storage Precautions:DON'T INGEST.MAJ INGRED ARE LOW
TOXICITY BY ALL ADMINISTRATED ROUTES.GIVEN IN LG DOSES TO PATIENTS
FOR DIAGNOSTIC PROCEDURES;NONHAZ FOR HANDLERS.(SUP)
Other Precautions:PROD:A RADIOPAQUE CONTRAST AGENT CONTAINING
DIATRIZOATE MEGLUMINE & DIATRIZOATE SODIUM WHICH ARE VERY POORLY
ABSORBED FRM GI TRACT.INTENDED FOR INTRAVASCULAR ADM UNDER DR'S
CARE.USE:VISUALIZE URINARY TRACT/KIDNESY/HEART/BRAIN/PERIP BLOOD
VE

Respiratory Protection:NONE SPECIFIED BY MANUFACTURER.
Ventilation:NONE SPECIFIED BY MANUFACTURER.
Protective Gloves:LATEX GLOVES
Eye Protection:CHEM SAFTY GOGGLES FOR HANDLING LG QUANT
Other Protective Equipment:PROT CLOTH.ADDN PROT CLOTH NEEDED WHEN
HANDLING LG QUANT OF PROD OR POTENTIAL FOR SPLASHING EXISTS.GOWN
Work Hygienic Practices:WASH HANDS/FACE AFT HANDLING THIS
FORMULATION.PROMPTLY REMOVE CONTAMIN CLOTH & WASH BEF REUSE.
Supplemental Safety and Health
FIREFIGHTING:W/WATER.FIGHT FIRE FRM MAX SAFE DISTANCE.DIVERT RUNOFF TO
SAFE AREA. HEALTH HAZ:CONVULSIONS,SHOCK. ADDN INFO ABOUT
USE/EFFECTS FOUND IN PAKG INSERT SUPPLIED W/PRODUCT.
HANDLE/STORAGE:STOR E @RM TEMP (20-25C).AVOID CONTACT
(INGEST/INHAL/SKIN/EYE).

HCC:T6
Boiling Pt:B.P. Text:N/AVAILABLE
pH:6-7.7
Solubility in Water:MISCIBLE
Appearance and Odor:COLORLESS TO PALE YELLOW AQUEOUS LIQUID, PRATICALLY
ODORLESS

Stability Indicator/Materials to Avoid:YES
NONE KNOWN
Stability Condition to Avoid:AVOID EXCESSIVE HEAT. PROTECT FROM LIGHT.
Hazardous Decomposition Products:THERMAL DECOMPOSITION OR BURNING MAY
PRODUCE NOXIOUS PROUDCTS INCLUDING CO, CO2, HI, IX (REDDISH-BROWN
GAS), NOX.

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/ALL LOCAL, STATE AND
FEDERAL REGULATIONS OR W/REGS OF COUNTRY IN WHICH MATL IS USED.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.