Product ID:DEPO-PROVERA CONTRACEPTIVE INJECTION
MSDS Date:06/30/1994
FSC:6505
NIIN:01-153-4445
MSDS Number: BXCPL

UPJOHN COMPANY, THE

7171 PORTAGE ROAD
KALAMAZOO, MI 49001-0199
US

Emergency Phone: 616-323-5122 24 HOURS

Info Phone: 30 PM)

Preparer: HEALTH & SAFETY REG AFFRS

Cage: 93703

PHARMACIA & UPJOHN

KALAMAZOO, MI 49001-0199 US

Telephone: 616-833-5122/616-833-7555

Cage: 93703

WATER

CAS: 7732-18-5

RTECS: ZC0110000

Fraction By Weight: <81%

PROVERA(MEDROXYPROGESTERONE ACETATE)

CAS: 71-58-9

RTECS: TU5010000

Fraction By Weight: 15%

CARBOWAX (POLYETHYLENE GLYCOL 3350)

Fraction By Weight: <3%

NON-HAZARDOUS INGREDIENTS

Fraction By Weight: <1%

LD50 LC50 Mixture:ORAL LD50 (RAT) IS >6.4G/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:YES OSHA:NO
Health Hazards Acute and Chronic:MFR DOES NOT REPORT ACUTE HEALTH
HAZARDS.RTECS REPORTS THAT ACUTE OVEREXPOSURE MAY CAUSE INCREASED
INTRAOCULAR PRESSURE(IN EYES).CHRONIC EXPOSURE MAY CAUSE
BREAKTHROUGH BLEEDING,CHANGES IN CERVICAL SE CRETIONS,CERVICAL
EROSION,CNS EFFECTS,THROMBOEMBOLYTIC DISORDERS(BLOOD CLOTS,ESP. IN
BRAIN AND HEART).
Explanation of Carcinogenicity:MEDROXYPROGESTERONE ACETATE IS LISTED BY
IARC AS GROUP 2B.POSSIBLE REPRODUCTIVE TOXIN,ESPECIALLY IN THE
FIRST 4 MONTHS.
Effects of Overexposure:CHRONIC:SPOTTING,WEIGHT GAIN OR
LOSS,CHOLESTATIC JAUNDICE(SYMPTOM IS DARK URINE),SKIN
DISCOLORATION,MENTAL DEPRESSION,BREAST TENDERNESS,EXCESSIVE MILK
FLOW,POSSIBLY INCREASE BODY TEMPERATURE OR NAUSEA .CNS
EFFECTS:NERVIOUSNESS,INSOMNIA,FATIGUE,DIZZINESS,POSSIBLY HEADACHE.
Medical Cond Aggravated by Exposure:PERSONS WITH HYPERSENSITIVITY TO
MEDROXYPROGESTERONE ACETATE,THROMBOPHLEBITIS,THROMBOEMBOLIC
DISORDER,CEREBRAL APOPLEXY,CARCINOMA OF THE BREAST,UNDIAGNOSED
VAGINAL BLEEDING OR PREGNANCY.

First Aid:SKIN:REMOVE CONTAMINATED CLOTHING;WASH WITH SOAP AND
WATER.EYES:FLUSH WITH WATER FOR 15 MINUTES.INHAL:REMOVE TO FRESH
AIR.GIVE OXYGEN OR ARTIFICIAL RESPIRATION IF NEEDED.INGEST:DO NOT
INDUCE VOMITING. GET PROMPT QUALIFIED MEDICAL ATTENTION.

Flash Point:NONE
Extinguishing Media:WATER,DRY CHEMICAL,CARBON DIOXIDE.
Fire Fighting Procedures:USE A SELF-CONTAINED BREATHING APPARATUS AND
FULL PROTECTIVE EQUIPMENT.
Unusual Fire/Explosion Hazard:FIRE CONDITIONS MAY EVOLVE TOXIC FUMES.

Spill Release Procedures:USE PROPER PROTECTIVE AND RESPIRATORY
EQUIPMENT.SWEEP OR VACUUM;DO NOT CREATE DUST;PLACE IN A DRY
CONTAINER FOR DISPOSAL.CLEAN SPILL AREA WITH WATER.AVOID
CONTAMINATION DRAINS.SMALL SPILLS CAN BE ABSO RBED WITH PAPER
TOWELS.
Neutralizing Agent:NOT APPLICABLE.

Handling and Storage Precautions:STORE IN A COOL,DRY,WELL-VENTILATED
PLACE.KEEP CONTAINER CLOSED WHEN NOT IN USE.KEEP AWAY FROM
CHILDREN.KEEP AWAY FROM LIGHT.
Other Precautions:FOLLOW LABEL DIRECTIONS.AVOID BREATHING DUST.AVOID
SKIN AND EYE CONTACT.

Respiratory Protection:NOT NEEDED IN NORMAL SERVICE.
Ventilation:USE LOCAL EXHAUST.
Protective Gloves:RUBBER.
Eye Protection:SAFETY GLASSES WITH SIDESHIELDS.
Other Protective Equipment:PROVIDE A LOCAL EYE WASH STATION.
Work Hygienic Practices:EXECISE GOOD LABORATORY PRACTICES.WASH HANDS
AFTER USE AND BEFORE EATING.
Supplemental Safety and Health
NDC 0009-0746-30/0009-0746-31.

HCC:N1
Solubility in Water:COMPLETE
Appearance and Odor:POWDER.WHITE TO OFF-WHITE SUSPENSION WHEN MIXED.

Stability Indicator/Materials to Avoid:YES
MANUFACTURER STATES NONE.
Stability Condition to Avoid:MANUFACTURER STATES NONE.
Hazardous Decomposition Products:CARBON DIOXIDE,CARBON MONOXIDE

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH FEDERAL,STATE AND
LOCAL REGULATIONS.

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This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.