Product ID:BLENOXANE
MSDS Date:03/01/1990
FSC:6505
NIIN:01-060-4278
MSDS Number: BHCPF

BRISTOL-MYERS US PHARMACEUTICAL & NUTRITIONAL GP.

2404 PENNSYLVANIA AVENUE
EVANSVILLE, IN 47721-0001
US

Emergency Phone: 812-429-5140

Info Phone: 812-429-5000

Cage: 29398

BRISTOL-MYERS US PHARMACEUTICAL & NUTRITIONAL GP.

EVANSVILLE, IN 47721-0001 US

Telephone: 812-429-5644

Cage: 29398

BLEOMYCIN

CAS: 11056-06-7

RTECS: EC5988000

BLEOMYCIN

CAS: 9041-93-4

RTECS: EC5991990

MINOR COMPONENTS

LD50 LC50 Mixture:ORAL LD50 (RAT) IS >200 MG/KG
Routes of Entry: Inhalation:NO Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE:INGESTION,CYTOTOXIC
AGENT.IMPORTANT DOSE-DEPENDENT EFFECTS FOLLOWING INJECTION INCLUDE
LUNG & SKIN/MUCOUS MEMBRANE CHANGES.TOXIC IF ABSORBED THROUGH
SKIN,WITH SIGNIFICANT DEGREE OF ABSORPTION IN WORKERS WITH SKIN
DISEASES;MAY CAUSE RASH.EYE CONTACT MAY CAUSE
CONJUNCTIVITIS.CHRONIC: POTENTIAL CARCINOGEN.
Explanation of Carcinogenicity:NO CARCINOGENICITY STUDIES HAVE BEEN
COMPLETED. MUTAGENIC POTENTIAL HAS BEEN DOCUMENTED IN ANIMALS.
Effects of Overexposure:NON-DOSE DEPENDENT EFFECTS FOLLOWING INJECTION
INCLUDE FEVER, CHILLS, HYPOTENSION AND WHEEZING. EYE AND SKIN
IRRITATION.
Medical Cond Aggravated by Exposure:STAFF MEMBERS WHO ARE PREGNANT OR
BREAST- FEEDING SHOULD BE TRANSFERRED TO OTHER DUTIES THAT DO NOT
INVOLVE HANDLING BLENOXANE, IF THEY SO REQUEST.

First Aid:INHALATION: GET MEDICAL ATTENTION IF APPROPRIATE.
EYES:IMMEDIATELY FLUSH WITH PLENTY OF WATER FOR 15 MINUTES HOLDING
EYELIDS OPEN. GET IMMEDIATE MEDICAL ATTENTION. SKIN:REMOVE
CONTAMINATED CLOTHING. W ASH WITH SOAP AND WATER. IF IRRITATION
PERSISTS, GET MEDICAL ADVICE. INGESTION: GET IMMEDIATE MEDICAL
ATTENTION IF APPROPRIATE.

Autoignition Temp:Autoignition Temp Text:NONE
Extinguishing Media:USE CARBON DIOXIDE, FOAM, DRY CHEMICAL, OR WATER
FOG.
Fire Fighting Procedures:NONE; MATERIAL IS IN GLASS VIALS WHICH WILL
NOT BURN.
Unusual Fire/Explosion Hazard:AVOID INHALATION AND SKIN CONTACT, DO NOT
GET IN EYES.

Spill Release Procedures:WIPE LIQUIDS WITH ABSORBENT GAUZE PADS. WIPE
SOLIDS WITH WET ABSORBENT GAUZE. CLEAN, USING BLEACH OR DETERGENT
AND WATER.
Neutralizing Agent:52 FOLD MOLAR EXCESS OF 5.25% NAOCL, OR A 3 FOLD
MOLAR EXCESS OF 1% KMNO4.

Handling and Storage Precautions:SHOULD BE STORED UNDER REFRIGERATION
(2 TO 8C)
Other Precautions:FEDERAL LAW PROHIBITS DISPENSING WITHOUT
PRESCRIPTION. SEE PACKAGE INSERT FOR RECOMMENDED MEDICAL USE. SEE
OSHA INSTRUCTION PUB. 8-1.1 FOR ADDITIONAL WORK PRACTICE GUIDELINES
FOR HANDLING THIS MATERIA L.

Respiratory Protection:IF ENGINEERING CONTROLS FAIL OR NON-ROUTINE USE
OR EMERGENCY OCCURS; USE NIOSH/MSHA APPROVED RESPIRATOR OR SUPPLIED
AIR RESPIRATOR OR SCBA, AS REQUIRED. USE IAW 29 CFR 1910.134 AND
MANUFACTURER'S RECO MMENDATIONS.
Ventilation:BIOLOGICAL SAFETY CABINET FOR PREPARATION, OR AS DETERMINED
APPROPRIATE BY INDUSTRIAL HYGIENIST.
Protective Gloves:DISPOSABLE SURGICAL LATEX GLOVES
Eye Protection:PLASTIC FACE SHIELD OR SPLASH GOGGLES
Other Protective Equipment:PROTECTIVE DISPOSABLE GOWN OF LOW
PERMEABILITY FABRIC WITH CLOSED FRONT, LONG SLEEVES AND ELASTIC
CUFFS.
Work Hygienic Practices:WASH THOROUGHLY BEFORE EATING OR SMOKING. DO
NOT EAT, DRINK, SMOKE, CHEW GUM, APPLY COSMETICS OR STORE FOOD IN
WORK AREA
Supplemental Safety and Health
PRE-EMPLOYMENT PHYSICAL EXAMINATIONAND HISTORY FOR ALL EMPLOYEES WITH
POTENTIAL EXPOSURE TO BLENOXANE IS RECOMMENDED. A COMPLETE BLOOD
COUNT, INCLUDING DIFFERENTIAL, SHOULD BE TAKEN TO PROVIDE A BASEL
INE. PERIODIC FOLLOW-UP EXAMINATIONS SHOULD BE DONE AT LEAST
ANNUALLY. KEEP A PERMANENT REGISTRY OF ALL STAFF INVOLVED.

HCC:K2
Melt/Freeze Pt:M.P/F.P Text: 160F, 71C
Solubility in Water:COMPLETE
Appearance and Odor:COLORLESS TO YELLOWISH POWDER (MAY TURN BLUE). NO
ODOR
Percent Volatiles by Volume:0

Stability Indicator/Materials to Avoid:YES
NO KNOWN HAZARDOUS INCOMPATIBILITIES.
Stability Condition to Avoid:WHEN STORED IN ORIGINAL CONTAINER, DRUG IS
STABLE TO THE EXIPRATION DATE INDICATED ON THE LABEL OF THE
PRODUCT.
Hazardous Decomposition Products:NONE KNOWN; BUT ASSUME A CARCINOGENIC
POTENTIAL.

Waste Disposal Methods:DISPOSAL SHOULD BE MADE IN ACCORDANCE WITH ALL
APPLICABLE FEDERAL, STATE AND LOCAL LAWS AND REGULATIONS.
INCINERATION IS RECOMMENDED.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.