Product ID:THIOGUANINE
MSDS Date:08/24/1988
FSC:6505
NIIN:01-146-8047
MSDS Number: BHHQJ

Emergency Phone: 919-248-3000

Info Phone: 919-248-3000

Cage: 5P291

Cage: 5P291

THIOGUANINE (6-THIOGUANINE OR

CAS: 154-42-7

RTECS: UP0740000

LD50 LC50 Mixture:LD50 ORAL RAT = 740 MG/KG
Routes of Entry: Inhalation:NO Skin:NO Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:THIOGUANINE HAS BEEN SHOWN TO BE
TERATOGENIC IN RATS. DRUGS SUCH AS THIOGUANINE ARE POTENTIAL
CARCINOGENS, MUTAGENS AND TERATOGENS. THIOGUANINE MAY CAUSE FETAL
HARM WHEN ADMINITERED TO A PREGNANT WOMA N.
Explanation of Carcinogenicity:MANUFACTURER STATES THIOGUANINE IS A
POTENTIAL CARCINOGEN, BUT IT IS NOT LISTED UNDER IARC,NTP OR OSHA.
Effects of Overexposure:NAUSEA, VOMITING, ANOREXIA, MALAISE,
HYPERTENSION, DIAPHORESIS, AND STOMATITIS MAY OCCUR. THE
SUPPRESSIVE EFFECT ON BONE MARROW AND AZOTEMIA IS LIKELY TO BE
DELAYED FOR SEVERAL DAYS.
Medical Cond Aggravated by Exposure:MANUFACTURER DID NOT SPECIFY.

First Aid:IF INGESTED, WASH MOUTH. IF INGESTION WAS RECENT, INDUCE
VOMIT, GASTRIC LAVAGE AND ADMINISTRATION OF CHARCOAL MAY REDUCE
ABSORPTION. CONTACT PHYSICIAN.

Extinguishing Media:USE CARBON DIOXIDE, FOAM, DRY CHEMICAL, OR WATER
FOG.
Fire Fighting Procedures:FIRE FIGHTERS SHOULD USE NIOSH APPROVED SCBA &
FULL PROTECTIVE EQUIPMENT WHEN FIGHTING CHEMICAL FIRE. USE WATER
SPRAY TO COOL NEARBY CONTAINERS EXPOSED TO FIRE.
Unusual Fire/Explosion Hazard:FIRE OR EXCESSIVE HEAT MAY CAUSE
PRODUCTION OF HAZARDOUS DECOMPOSITION PRODUCTS.

Spill Release Procedures:SWEEP UP AND PLACE IN APPROPIATE DISPOSAL
CONTAINER.

Handling and Storage Precautions:KEEP IN ORIGINAL CONTAINER TIGHTLY
CLOSED. PROTECT FROM LIGHT.
Other Precautions:NONE.

Respiratory Protection:NONE REQUIRED.
Ventilation:NORMAL ROOM VENTILATION.
Protective Gloves:NONE REQUIRED.
Eye Protection:NONE REQUIRED.
Other Protective Equipment:NONE.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
MSDS SUPPLIED BY MANUFACTURER WAS FOR BULK AMOUNT. HMIS MODIFIED MSDS
FOR TABLET FORM. THIOGUANINE IS AN ANTINEOPLASTIC DRUG.

HCC:N1
Solubility in Water:APPRECIABLE.
Appearance and Odor:SLIGHTLY YELLOW POWDER WITH NO ODOR.

Stability Indicator/Materials to Avoid:YES

Waste Disposal Methods:CONTACT YOUR LOCAL ENVIRONMENTAL OFFICER.
ARRANGE FOR CHEMICAL INCINERATION OR SUPERVISED BURIAL AT AN
APPROVED TOXIC WASTE FACILITY. DISPOSE OF IN ACCORDANCE WITH ALL
APPLICABLE FEDERAL, STATE AND LO CAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.