Product ID:BUSULFAN
MSDS Date:08/24/1988
FSC:6505
NIIN:00-660-1634
MSDS Number: BHHYR

Emergency Phone: 919-248-3000

Info Phone: 919-248-3000

Cage: 5P291

Cage: 5P291

BUSULFAN (1,4-BUTANEDIOL DIMETHYLSULFONATE OR MYLERAN)

CAS: 55-98-1

RTECS: EK1750000

LD50 LC50 Mixture:LD50 (ORAL MOUSE) IS 120 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:YES IARC:YES OSHA:NO
Health Hazards Acute and Chronic:HAS POWERFUL CYTOTOXIC PROPERTIES. MAY
DEPRESS BONE MARROW AND IS VESICANT AND NASAL IRRITANT.BUSULFAN IS
MUTAGENIC IN MOUSE,AND POSSIBLY,IN MAN.MAY CAUSE FETAL HARM WHEN
ADMINISTERED TO A PREGNANT WO MAN.INTERFERES WITH SPERMATOGENESIS
IN EXPERIMENTAL ANIMALS *CONTINUES IN SUPPLEMENTAL DATA*
Explanation of Carcinogenicity:BUSULFAN IS A CONFIRMED CARCINOGEN BY
IARC AND NTP.
Effects of Overexposure:NASAL IRRITANT. CAUSES BLISTERS.
Medical Cond Aggravated by Exposure:NONE NOTED.

First Aid:EYES:RINSE IMMEDIATELY WITH PLENTY OF WATER.SEE DOCTOR.
SKIN:WASH OFF SKIN WITH PLENTY OF WATER.SEE DOCTOR IF CONTACT IS
PROLONGED. INHALATION:REMOVE TO FRESH AIR.SEE DOCTOR.
INGESTION:WASH OUT MOUTH. GIVE FLUIDS.INDUCE VOMIT OR GASTRIC
LAVAGE IF INGESTION WAS RECENT.SEE DOCTOR.GIVE ACTIVATED CHARCOAL
IF INGESTION WAS RECENT.DAILY BLOOD COUNTS ARE NECESSARY FOR AT
LEAST 4 WEEKS.

Extinguishing Media:USE CARBON DIOXIDE, FOAM, DRY CHEMICAL, OR WATER
FOG.
Fire Fighting Procedures:FIRE FIGHTERS SHOULD USE NIOSH APPROVED SCBA &
FULL PROTECTIVE EQUIPMENT WHEN FIGHTING CHEMICAL FIRE. USE WATER
SPRAY TO COOL NEARBY CONTAINERS EXPOSED TO FIRE.
Unusual Fire/Explosion Hazard:FIRE OR EXCESSIVE HEAT MAY CAUSE
PRODUCTION OF HAZARDOUS DECOMPOSITION PRODUCTS.

Spill Release Procedures:WEAR SUITABLE PROTECTIVE CLOTHING.SWEEP UP
MINIMIZING DUST EVOLUTION.TRANSFER TO CLOSED DISPOSAL
CONTAINER.DECONTAMINATE AREA WITH DILUTE CAUSTIC SODA AND SODIUM
HYPOCHLORITE SOLUTION.
Neutralizing Agent:DILUTE CAUSTIC SODA AND SODIUM HYPOCHLORITE
SOLUTION.

Handling and Storage Precautions:STORE IN COOL, DRY, WELL VENTILATED
AREA. PROTECT FROM PHYSICAL DAMAGE, HEAT AND IGNITION SOURCES. KEEP
CONTAINERS CLOSED. PROTECT FROM LIGHT.
Other Precautions:NONE NOTED.

Respiratory Protection:FULL AIR-SUPPLIED SUIT IS RECOMMENDED OR AN
AIR-SUPPLIED HOOD WITH FULL BODY COVERING.
Ventilation:LOCAL EXHAUST.
Protective Gloves:DOUBLE LATEX
Eye Protection:CHEMICAL SAFETY GOGGLES
Other Protective Equipment:AVOID ALL CONTACT BY WEARING FULL BODY
PROTECTIVE CLOTHING (FOR EXAMPLE TYVEK).
Work Hygienic Practices:WASH THROUGHLY AFTER HANDLING AND BEFORE
EATING. LAUNDER CONTAMINATED CLOTHING BEFORE REUSE.
Supplemental Safety and Health
THIS IS AN ANTINEOPLASTIC DRUG. *CONTINUED FROM HEALTH HAZARDS:THERE
HAVE BEEN CLINICAL REPORTS OF STERILITY,AZOOSPERMIA AND TESTICULAR
ATROPHY IN MALE PATIENTS RECEIVING THIS DRUG*

HCC:T6
Melt/Freeze Pt:M.P/F.P Text:243F,117C
Solubility in Water:INSOLUBLE
Appearance and Odor:WHITE ALMOST ODORLESS CRYSTALLINE POWDER.

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:CARBON DIOXIDE, CARBON MONOXIDE,
INCOMPLETELY BURNED CARBON PRODUCTS.

Waste Disposal Methods:NOTIFY YOUR LOCAL ENVIRONMENTAL OFFICER. DISPOSE
OF IN ACCORDANCE WITH ALL APPLICABLE FEDERAL, STATE AND LOCAL LAWS
AND REGULATIONS. PRODUCT MAY BE INCINERATED. WASH WATERS AND RINSES
SHOULD BE DISCHA RGED TO AN APPROVED SEWERAGE SYSTEM.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.