Product ID:LEUKERAN
MSDS Date:08/24/1988
FSC:6505
NIIN:01-145-6378
MSDS Number: BHHZL

Emergency Phone: 919-248-3000

Info Phone: 919-248-3000

Cage: 5P291

Cage: 5P291

CHLORAMBUCIL (SARA III)

CAS: 305-03-3

RTECS: ES7525000

EPA Report Quantity: 10 LBS

DOT Report Quantity: 10 LBS

LD50 LC50 Mixture:LD50 (ORAL MOUSE) IS 123 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:YES IARC:YES OSHA:NO
Health Hazards Acute and Chronic:ACUTE:CENTRAL NERVOUS SYSTEM TOXICITY.
CHRONIC:CAN SEVERELY SUPPRESS BONE MARROW FUNCTION. CHLORAMBUCIL
IS PROBABLY MUTAGENIC AND TERATOGENIC IN HUMANS. MAY CAUSE FETAL
HARM WHEN ADMINISTERED TO A PR EGNANT WOMAN. THIS PRODUCT PRODUCES
HUMAN INFERTILITY.
Explanation of Carcinogenicity:NONE OF THE CHEMICALS IN THIS PRODUCT IS
LISTED BY IARC, NTP OR OSHA AS A CARCINOGEN.
Effects of Overexposure:CHLORAMBUCIL IS A CONFIRMED HUMAN CARCINOGEN BY
IARC, NTP.
Medical Cond Aggravated by Exposure:PERSONS WITH A HISTORY OF NERVOUS
DISORDERS MAY BE AT INCREASED RISK FROM EXPOSURE.

First Aid:INHALATION: REMOVE SUBJECT TO FRESH AIR. EYE: FLUSH WITH
PLENTY OF WATER FOR 15 MINUTES. GET IMMEDIATE MEDICAL ATTENTION.
SKIN: WASH WITH SOAP AND WATER. INGESTION: WASH OUT MOUTH. GIVE
PLENTY OF FLUI DS. INDUCE VOMITING,GASTRIC LAVAGE AND ADMINISTER
CHARCOAL IF INGESTION WAS RECENT.GET IMMEDIATE MEDICAL ATTENTION.
*CONTINUES IN SUPPLEMENTAL DATA*

Extinguishing Media:USE CARBON DIOXIDE, FOAM, DRY CHEMICAL, OR WATER
FOG.
Fire Fighting Procedures:FIRE FIGHTERS SHOULD USE NIOSH APPROVED SCBA &
FULL PROTECTIVE EQUIPMENT WHEN FIGHTING CHEMICAL FIRE. USE WATER
SPRAY TO COOL NEARBY CONTAINERS EXPOSED TO FIRE.
Unusual Fire/Explosion Hazard:FIRE OR EXCESSIVE HEAT MAY CAUSE
PRODUCTION OF HAZARDOUS DECOMPOSITION PRODUCTS.

Spill Release Procedures:WEAR SUITABLE PROTECTIVE CLOTHING.SWEEP
UP,MINIMIZING DUST EVOLUTION.TRANSFER TO CLOSED DISPOSAL
CONTAINER.DECONTAMINATE AREA WITH 5% CAUSTIC SODA SOLUTION.THEN
WASH DOWN WITH WATER.COLLECT AND TREAT CAUSTIC WATER WASHES BEFORE
DISCHARGE.
Neutralizing Agent:5% CAUSTIC SODA SOLUTION.

Handling and Storage Precautions:STORE IN COOL, DRY, WELL VENTILATED
AREA. PROTECT FROM PHYSICAL DAMAGE, HEAT AND IGNITION SOURCES. KEEP
CONTAINERS CLOSED.
Other Precautions:NONE.

Respiratory Protection:AIR-SUPPLIED SUIT IS RECOMMENDED OR AIR-SUPPLIED
HOOD WITH FULL BODY COVERING.
Ventilation:LOCAL EXHAUST VENTILATION.
Protective Gloves:DOUBLE LATEX.
Eye Protection:GOGGLES.
Other Protective Equipment:TYVEK JUMPSUIT OR OTHER FULL BODY COVERING.
Work Hygienic Practices:WASH THROUGHLY AFTER HANDLING AND BEFORE
EATING. LAUNDER CONTAMINATED CLOTHING BEFORE REUSE.
Supplemental Safety and Health
THIS IS AN ANTINEOPLASTIC DRUG. *EMERGENCY AND FIRST
AID,CONTINUED:CONTROL OF HYPERACTIVITY OR CONVULSIONS WILL REQUIRE
SEDATION;THE ROUTE BEING DICTATED BY THE CONDITION.DAILY BLOOD
COUNTS ARE NECES SARY FOR 2 WEEKS.TRANSFUSION OF FRESH BLOOD AND
BARRIER NURSING WOULD BE REQUIRED IF BONE MARROW SUPPRESSION
OCCURS.

HCC:T6
Melt/Freeze Pt:M.P/F.P Text:150F,65.5C
Solubility in Water:SLIGHT.
Appearance and Odor:WHITE CRYSTALLINE POWDER WITH A SLIGHT ODOR.

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:CARBON DIOXIDE, CARBON MONOXIDE,
INCOMPLETELY BURNED CARBON PRODUCTS.

Waste Disposal Methods:CONTACT YOUR LOCAL ENVIRONMENTAL OFFICER.
ARRANGE FOR INCINERATION. DISPOSE OF IN ACCORDANCE WITH ALL
APPLICABLE FEDERAL, STATE AND LOCAL LAWS AND REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.