Product ID:BECONASE
MSDS Date:10/01/1988
FSC:6505
NIIN:00N043729
MSDS Number: BTGWZ

GLAXO INC

FIVE MOORE DR
RESEARCH TRAINGLE PARK, NC 27709
US

Emergency Phone: 919-248-2100;919-248-2700

Info Phone: 919-248-2100;919-248-2700

Cage: 34006

GLAXO WELLCOME INC.

13398 DURHAM, NC 27709 US

Telephone: 919-248-2100

Cage: 34006

PREGNA-1-4-DIENE-3,20-DIONE,

CAS: 5534-09-8

RTECS: TU3805000

Fraction By Weight: 100%

OSHA PEL N/K

ACGIH TLV: N/K

(BECLOMETHASONE DIPROPIONATE)

RTECS: 9999999ZZ

RETENTION W/SWELL, ABNORM FAT DEPOSITION, WT

RTECS: 9999999ZZ

DIABETES, & LOWERING OF BODY'S RESISTANCE TO

RTECS: 9999999ZZ

CAUSE BIRTH DEFECTS IN LAB ANIMALS INCL DEFECTS OF

RTECS: 9999999ZZ

TO HUMAN RISK IS NOT KNOWN. FOR THERAP USE DURING

RTECS: 9999999ZZ

RISK TO FETUS. CHRONIC OVEREXP MAY CAUSE SKIN RASH,

RTECS: 9999999ZZ

PROT & PROT CLTHG. COLLECT SPILLAGE BY

RTECS: 9999999ZZ

IN LBLD, SEALED CONTR FOR REUSE/DISP. WASH AREA

RTECS: 9999999ZZ

FOR RESP PROT (ANSI Z88.2) & RESP EQUIP MFR

RTECS: 9999999ZZ

FOR EXPOSURE OF CONCERN .

RTECS: 9999999ZZ

EXPOSED TO DUST SHOULD CHANGE CLOTHES AND

RTECS: 9999999ZZ

LD50 LC50 Mixture:ORAL LD50 (RAT) IS >5 G/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: SKIN: RPTD SKIN CONT CAN RSLT
IN "THINNING" OF SKIN W/INCR TENDENCY TO BRUISING. RPTD SKIN CONT
CAN CAUSE INCR SUSCEPTIBILITY TO SOME SKIN INFECTIONS & MAY ALSO
CAUSE RED SKIN RASH. INHAL: RARE CASES OF ALLERGIC RXN HAVE BEEN
REPORTED IN INDIVIDUALS TAKING BECLOMETHASONE DIPROPIONATE BY
INHALER(EFTS OF OVEREXP)
Explanation of Carcinogenicity:NOT RELEVANT
Effects of Overexposure:HLTH HAZ:MEDICINALLY. THESE RXNS INCL RASHES,
HIVES, CHEST TIGHTNESS, WHEEZING & SWELLING. BECLOMETHASONE
DIPROPIONATE IS ABSORBED THRU ALL RTS OF EXPOS INCL SKIN, INGEST &
INHAL. GENERALIZED SIDE EFT S MAY OCCUR AFTER PRLNGD LOW DOSE
ABSORP INCL SUPPRESSION OF ADRENAL CORTEX, A SERIOUS MED CNDTN.
RSLTS IN A (SUPP DATA)
Medical Cond Aggravated by Exposure:NONE SPECIFIED BY MANUFACTURER.

First Aid:EYES: FLUSH THORO W/LG AMTS OF WATER FOR @ LST 15 MIN. OBTAIN
MED ATTN. SKIN: REMOVE CONTAMD CLTHG. THORO WASH ALL AFFECTED AREAS
W/SOAP & WATER. OBTAIN MED ATTN. INHAL: REMOVE TO FRESH AIR. IF
BRTHG IS DFCLT/CEASES, GIVE OXYGEN/CARDIOPULMONARY RESUSCITATION.
KEEP WARM & @ REST. OBTAIN MED ATTN. INGEST: RINSE MOUTH, GIVE LG
QTY OF WATER & ENCOURAGE VOMIT. OBTAIN MED ATTN.

Extinguishing Media:WATER SPRAY, FOAM, MULTI-PURPOSE DRY CHEMICAL.
Fire Fighting Procedures:WEAR NIOSH/MSHA APPROVED SCBA AND FULL
PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:AS WITH ANY ORGANIC DUST, THERE IS
POTENTIAL FOR EXPLOSION WHEN SUSPENDED IN AIR IN HIGH
CONCENTRATIONS.

Spill Release Procedures:FULL PROT EQUIP SHOULD BE WORN WHERE THERE IS
POTNTL FROM SKIN EXPOS/A RISK OF DUST INHAL. NIOSH/MSHA APPRVD
SCBA, SUPPLIED AIR RESP/AIR PURIFYING RESP SHOULD BE USED TO AVOID
INHAL. BODY CONT SHOULD BE AVOIDED BY UTILIZING GLOVES, EYE (ING
8)
Neutralizing Agent:NONE SPECIFIED BY MANUFACTURER.

Handling and Storage Precautions:USE STORAGE PRACTICES THAT WILL
MINIMIZE GENERATION OF DUST.
Other Precautions:NONE SPECIFIED BY MANUFACTURER.

Respiratory Protection:RESP PROT EQUIP SHOULD BE WORN WHEN WORKERS ARE
EXPOSED TO AIRBORNE DUST LEVELS THAT EXC EED ESTIMATED SAFE WORKING
LEVEL. RECOM FOR RESP SELECTION ISSUED BY NATL INSTITUTE FOR OCCUP
SFTY & HLTH (NIOS H), AMERICAN NATL STD PRACTICES (ING 10)
Ventilation:PROVIDE LOCAL EXHAUST VENTILATION SYSTEM AT THE SOURCE OF
DUST GENERATION.
Protective Gloves:IMPERVIOUS GLOVES .
Eye Protection:ANSI APPRVD CHEM SAFETY GOGGLES .
Other Protective Equipment:A PROT OUTER GARMENT MAY PROVIDE ADEQ WORKER
PROT. IN DUSTY AREAS, FULL BODY PROT SHOULD BE USED.
Work Hygienic Practices:SPECIAL CARE SHOULD BE TAKEN TO ENSURE THAT
CONTAMD CLTHG & EQUIP ARE PROPERLY CLEANED AFTER USE. WORKERS (ING
12)
Supplemental Safety and Health
EFTS OF OVEREXP: DECR ABILITY OF BODY TO SECRETE LG AMTS OF CORTISOL IN
RESPONSE TO STRESS (SUCH AS SERIOUS ILLNESS) . SYMPS OF SUPPRESSION
MAY NOT OCCUR AS LONG AS BECLOMETHASONE DIPROPIONATE EXPOS R
EMAINS. SIDE EFTS WHICH CAN OCCUR IN INDIVIDUALS TAKING
BECLOMETHASONE DIPROPIONATE MEDICINALLY INCL FLUID & SALT (ING 3

HCC:N1
Melt/Freeze Pt:M.P/F.P Text:414F,212C
Solubility in Water:VERY SLIGHTLY SOL
Appearance and Odor:A WHITE TO CREAMY WHITE POWDER; ODORLESS

Stability Indicator/Materials to Avoid:YES
NO KNOWN INCOMPATIBILITIES.
Stability Condition to Avoid:EXTREME HEAT; MATERIAL DECOMPOSES AT 414F.
Hazardous Decomposition Products:THERMAL DECOMPOSITION PRODUCTS INCLUDE
TOXIC AND CORROSIVE CHLORIDE VAPORS.

Waste Disposal Methods:INCINERATE AT AN APPROVED FACILITY I/A/W
FEDERAL, STATE AND LOCAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.