Product ID:DEPO-TESTADIOL STERILE SOLUTION
MSDS Date:06/30/1994
FSC:6505
NIIN:01-158-4350
MSDS Number: BWFCH

UPJOHN COMPANY, THE

7171 PORTAGE ROAD
KALAMAZOO, MI 49001-0199
US

Emergency Phone: 616-323-5122 24 HOURS

Info Phone: 30 PM)

Preparer: HEALTH & SAFETY REG AFFRS

Cage: 93703

PHARMACIA & UPJOHN

KALAMAZOO, MI 49001-0199 US

Telephone: 616-833-5122/616-833-7555

Cage: 93703

COTTONSEED OIL

CAS: 8001-29-4

RTECS: GN2815000

Fraction By Weight: 94%

CYCLOPENTANEPROPIONATE TESTOSTERONE

CAS: 58-20-8

RTECS: XA3066000

Fraction By Weight: 5%

CHLOROBUTANOL

CAS: 57-15-8

Fraction By Weight: <1%

17-CYCLOPENTANEPROPIONATE ESTRADIOL

CAS: 313-06-4

RTECS: KG4600000

Fraction By Weight: <1%

LD50 LC50 Mixture:LD50 SUBCUTANEOUS RAT IS >2000MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:YES OSHA:NO
Health Hazards Acute and Chronic:TESTOSTERONE MAY CAUSE
SWELLING,MASCULINIZATION IN FEMALES AND INHIBITION PF TESTICULAR
FUNCTION IN MALES.ESTRADIOL CAN BE ABSORBED THROUGH THE SKIN OR
RESPIRATORY TRACT.FEMALES MAY EXPERIENCE VAGINAL BLEEDING,BREAST
CHANGES(TENDERNESS,ENLARGEMENT,SECRETIONS) ...(CONT'D IN SIGNS AND
SYMPTOMS)
Explanation of Carcinogenicity:ESTRADIOL IS LISTED BY IARC AS GROUP
2B(SUFFICIENT EVIDENCE).TESTOSTERONE IS ALSO LISTED BY IARC.
Effects of Overexposure:MALES MAY EXPERIENCE BREAST ENLARGEMENT,LOSS OF
LIBIDO,TESTICULAR SHRINKING. ADVERSE
EFFECTS:DIZZINESS,NAUSEA,VOMITING,ABDOMINAL
CRAMPS,ANOREXIA,MIGRAINE HEADACHES,MENTAL
DEPRESSION,DIARRHEA,HYPERTENS ION,SKIN HYPERPIGMENTATION(ESP.FACE
ANDNIPPLES).OCULAR CURVATURE(CAUSING DISCOMFORT WITH CONTACT
LENSES) (SEE SUPPL)
Medical Cond Aggravated by Exposure:PERSONS WITH HYPERSENSITIVITY TO
THE DRUG,LIVER,HEART,KIDNEY,UNDIAGNOSED ABNORMAL GENITAL
BLEEDING,EXISTING THROMBOEMBOLYTIC DISEASE,PROSTATIC,MAMMARY OR
UTERINE CANCER(OR HISTORY THEREOF),PREGNANCY.

First Aid:SKIN:REMOVE CONTAMINATED CLOTHING;WASH WITH SOAP AND
WATER.EYES:FLUSH WITH WATER FOR 15 MINUTES.INHAL:REMOVE TO FRESH
AIR.GIVE OXYGEN OR ARTIFICIAL RESPIRATION IF NEEDED.INGEST:DO NOT
INDUCE VOMITING. GET PROMPT QUALIFIED MEDICAL ATTENTION.

Flash Point:NONE
Extinguishing Media:WATER,DRY CHEMICAL,CARBON DIOXIDE.
Fire Fighting Procedures:USE A SELF-CONTAINED BREATHING APPARATUS AND
FULL PROTECTIVE EQUIPMENT.
Unusual Fire/Explosion Hazard:FIRE CONDITIONS MAY EVOLVE TOXIC FUMES.

Spill Release Procedures:USE PROPER VENTILATION AND RESPIRATORY
EQUIPMENT.SMALL SPILLS CAN BE ABSORBED W/PAPER TOWELS.LARGE SPILLS
SHOULD BE VACUUMED OR SCOOPED UP;PLACE IN AN APPROPRIATE CONTAINER
FOR DISPOSAL.AVOID CONTAMIN ATION OF SEWER.CLEAN SPILL AREA WITH
DILUTE BLEACH
Neutralizing Agent:NOT APPLICABLE.

Handling and Storage Precautions:STORE IN A COOL,DRY,WELL-VENTILATED
PLACE.KEEP CONTAINER CLOSED WHEN NOT IN USE.KEEP AWAY FROM
CHILDREN.KEEP AWAY FROM LIGHT.
Other Precautions:FOLLOW LABEL DIRECTIONS.AVOID BREATHING DUST.AVOID
SKIN AND EYE CONTACT.

Respiratory Protection:NOT NEEDED IN NORMAL SERVICE.
Ventilation:USE LOCAL EXHAUST.
Protective Gloves:RUBBER.
Eye Protection:SAFETY GLASSES WITH SIDESHIELDS.
Other Protective Equipment:PROVIDE A LOCAL EYE WASH STATION.
Work Hygienic Practices:EXECISE GOOD LABORATORY PRACTICES.WASH HANDS
AFTER USE AND BEFORE EATING.
Supplemental Safety and Health
ESTROGENS HAVE A WEAK ANABOLIC EFFECT AND MAY CAUSE SODIUM AND FLUID
RETENTION(BLOATING,EDEMA).ESTROGENS AFFECT CALCIUM DEPOSITION IN
BONES AND BLOOD CALCIUM CONCENTRATION. NDC 009-0253-02.

HCC:N1
Solubility in Water:COMPLETE
Appearance and Odor:LIQUID.COLOR AND ODOR NOT REPORTED.

Stability Indicator/Materials to Avoid:YES
MANUFACTURER STATES NONE.
Stability Condition to Avoid:MANUFACTURER STATES NONE.
Hazardous Decomposition Products:CARBON DIOXIDE,CARBON MONOXIDE

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE WITH FEDERAL,STATE AND
LOCAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.