Product ID:TAXOL FOR INJECTION,CONCENTRATE
MSDS Date:01/14/1994
FSC:6505
NIIN:00F051833
MSDS Number: CCFVF

BRISTOL-MYERS SQUIBB PHARMACEUTICAL GROUP

1 SQUIBB DRIVE
NEW BRUNSWICK, NJ 08903-5000
US

Emergency Phone: 908-519-3843

Info Phone: 908-519-3843

Cage: BRIST

BRISTOL-MYERS SQUIBB PHARMACEUTICAL GROUP

191 NEW BRUNSWICK, NJ 08903 US

Telephone: 908-519-2385

Cage: BRIST

TAXOL, PACLITAXEL *96-3*

CAS: 33069-62-4

RTECS: DA8340700

Fraction By Weight: 0.6%

CASTOR OIL, ETHOXYLATED

CAS: 61791-12-6

RTECS: GO5661000

Fraction By Weight: >1%

ETHANOL (ETHYL ALCOHOL), TECSOL, ALCOHOL, SYNASOL * 96-3 *

CAS: 64-17-5

RTECS: KQ6300000

Fraction By Weight: >1%

OSHA PEL 1000 PPM

ACGIH TLV: 1000 PPM

Routes of Entry: Inhalation:YES Skin:NO Ingestion:NO
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:INHALATION: UPPER RESPIRATORY TRACT
IRRITATION. SKIN: CONTACT DERMATITIS, IRRITATION. EYES:
CONJUNCTIVITIS. MAY BE HARMFUL TO FETUS. REPEATED EXPOSURE TO
PACLITAXEL IN SUFFICIENT DOSE MAY AFFECT BONE MARROW, PERIPHERAL
NERVOUS SYSTEM, GI TRACT & REPRODUCTIVE SYSTEMS.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:IRRITATION, DIZZINESS, NAUSEA,
LIP/TONGUE/THROAT SWELLING, BURNING SENSATION, WHEEZING, DRY COUGH,
SHORTNESS OF BREATH, HEADACHES, RASH, PERIORBITAL NUMBNESS,
PHOTOSENSITIVITY, FLUSHING, PREVENTRICULA R CONTRACTIONS, CHEST
PAIN, CHEST TIGHTNESS, TINGLING, REDNESS, BLOTCHES, PRURITUS,
CELLULITIS, SUBSTERNAL CHEST PAIN.
Medical Cond Aggravated by Exposure:PRE-EXISTING ASTHMA, ANEMIA/OTHER
FORMS OF BONE MARROW SUPPRESSION, CARDIAC ARRHYTHMIAS.

First Aid:INGESTION: ONLY INDUCE VOMITING AT INSTRUCTIONS OF A
PHYSICIAN. NEVER GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON.
INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
SKIN/EYES: FLUSH W/RU NNING WATER FOR 15 MINS. OBTAIN
MEDICALATTENTION IN ALL CASES.

Flash Point:60F (SEE SUPP)
Lower Limits:4.3
Upper Limits:19
Extinguishing Media:WATER, DRY CHEMICAL, CO2, ALCOHOL FOAM.
Fire Fighting Procedures:WEAR SCBA, FLAME & CHEMICAL RESISTANT
CLOTHING/BOOTS/GLOVES. EVACUATE PERSONNEL UPWIND. SAFELY REMOVE
UNNEEDED MATERIAL & COOL W/WATER FROM MAXIMUM DISTANCE.
Unusual Fire/Explosion Hazard:PRODUCT IS ASSUMED TO BE FLAMMABLE.

Spill Release Procedures:REMOVE IGNITION SOURCES. WEAR SUITABLE
PROTECTIVE CLOTHING & EQUIPMENT. WIPE UP W/ABSORBENT TOWELS/OTHER
ABSORBENT MATERIAL. PLACE COLLECTED MATERIAL INTO A SUITABLE
CONTAINER FOR DISPOSAL/RECLAMATION . DECONTAMINATE. WASH TWICE
W/DETERGENT& WATER.
Neutralizing Agent:SODIUM CARBONATE SOLUTION/METHANOLIC POTASSIUM
HYDROXIDE.

Handling and Storage Precautions:STORE BETWEEN 35.6-46.4F. DON'T BREAK
VIALS/SPILL CONTENTS. AVOID INHALATION, SKIN/EYE CONTACT WITH THIS
MATERIAL.
Other Precautions:SEE RELEVANT GUIDANCE FOR HANDLING OF CYTOTOXIC
MATERIALS.

Respiratory Protection:INSUFFICIENT ENGINEERING CONTROLS/BSC ISN'T
AVAILABLE: APPROVED RESPIRATOR W/HEPA FILTERS/POWERED AIR-PURIFYING
RESPIRATOR W/HEPA CARTRIDGES. HANDLING LARGE QUANTITIES: ORGANIC
VAPOR CARTRIDGES IN COM BINATION W/HEPA CARTRIDGES.
Ventilation:LOCAL MECHANICAL EXHAUST: RECOMMENDED. BIOLOGICAL SAFETY
CABINET SHOULD BE USED FOR PREPARATION OF THIS DRUG.
Protective Gloves:IMPERVIOUS, RUBBER, NEOPRENE DOUBLED UP
Eye Protection:CHEMICAL SAFETY GOGGLES
Other Protective Equipment:PROTECTIVE LAB COAT, IMPERVIOUS DISPOSABLE
COVERALLS W/CLOSED FRONT, LONG SLEEVES & ELASTIC CUFFS, BOOTS.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
BOILING POINT & FLASH POINT INFORMATION IS FOR ETHYL ALCOHOL.
SOLUBILITY IN WATER: BULK TAXOL-0.252 MG/L AT PH 5; 0.172 MG/L AT
PH 7; 0.249 MG/L AT PH9.

Boiling Pt:B.P. Text:173F (SUPP)
Solubility in Water:(SEE SUPP)
Appearance and Odor:5 ML VIALS CONTAINING LIQUID (MAY APPEAR CLOUDY).

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZERS, ACIDS, BASES.
Stability Condition to Avoid:HEAT, OPEN FLAME, EXPIRATION DATE.
Hazardous Decomposition Products:CO, CO2, OXIDES OF NITROGEN.

Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
REGULATIONS. INCINERATION AT AN APPROVED FACILITY IS RECOMMENDED.
FLAMMABLE LIQUID UN1170. EPA HAZARDOUS WASTE NO. D001.

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disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
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particular situation.