Product ID:VENTOLIN ALBUTEROL, USP INHALATION AEROSOL
MSDS Date:12/19/1994
FSC:6505
NIIN:01-394-1721
Status Code:A
MSDS Number: CJFHF

GLAXO INC

5 MOORE DR
RESEARCH TRIANGLE PARK, NC 27709
US

Emergency Phone: 919-248-2100/2700

Info Phone: 919-248-2100/2700

Cage: 34006

GLAXO WELLCOME INC.

13398 DURHAM, NC 27709 US

Telephone: 919-248-2100

Cage: 34006

DICHLORODIFLUOROMETHANE

CAS: 75-71-8

RTECS: PA8200000

OSHA PEL 4950 MG/M3;1000 PPM

ACGIH TLV: 4950 MG/M3;1000 PPM

EPA Report Quantity: 5000 LBS

DOT Report Quantity: 5000 LBS

FLUOROTRICHLOROMETHANE

CAS: 75-69-4

RTECS: PB6125000

OSHA PEL 5600 MG/M3;1000 PPM

ACGIH TLV: 1000 PPM

EPA Report Quantity: 5000 LBS

DOT Report Quantity: 5000 LBS

ALBUTEROL

CAS: 18559-94-9

RTECS: ZE4400000

Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Health Hazards Acute and Chronic:SKIN: MAY BE ABSORBED. CAN CAUSE
ALLERGIC RASH. THE PROPELLANTS IN THE INHALER CAN CAUSE
IRRITATION/FROSTBITE. INHALATION: CAN BE ABSORBED FROM THE
RESPIRATORY TRACT. HIGH PROPELLANT CONCENTRATIONS IN THE AIR MAY
CAUSE SUFFOCATION. EYES: MAY BE IRRITATING. INGESTION: COULD RESULT
IN THE SAME ADVERSE EFFECTS WHEN USED MEDICALLY.
Effects of Overexposure:REDNESS, ITCHING, IRRITATION, FROSTBITE,
DIFFICULTY BREATHING, SWELLING OF THE FACE & AIRWAYS, SUFFOCATION,
DIZZINESS, DISORIENTATION, UNCOORDINATION, NAUSEA, VOMITING,
IRREGULAR HEARTBEAT/LOSS OF CON SCIOUSNESS, FINE MUSCLE TUMORS,
CRAMPS, HEADACHE,VERTIGO, NERVOUSNESS, HEARTBURN, CHEST PAINS,
RAPID PULSE, PALPITATIONS, INCREASED BLOOD PRESSURE,HIVES/RASH
Medical Cond Aggravated by Exposure:INDIVIDUALS HYPERSENSITIVE TO
BETA-ADRENERGIC AGENTS LIKE ALBUTEROL, PERSONS W/CARDIOVASCULAR
DISORDERS, SEIZURE DISORDERS.

First Aid:EYES: FLUSH W/LARGE AMOUNTS OF COOL WATER FOR 15 MINS. SKIN:
WASH W/SOAP& WATER. DON'T USE HOT WATER. INHALATION: IF NOT
BREATHING, GIVE CPR/OXYGEN. FOR RESUSCITATION FOLLOWING EXPOSURE TO
PROPELLANTS , EPINEPHRINE & RELATED DRUGS MAY BE CONTRAINDICATED.
INGESTION: IF AWAKE & ABLE TO SWALLOW, RINSE MOUTH W/WATER. NEVER
GIVE ANYTHING BY MOUTH IF UNCONSCIOUS/HAVING CONVULSIONS. OBTAIN
MEDICAL ATTENTI ON IN ALL CASES. NOTES TO PHYSICIAN: THE
PROPELLANTS DICHLORODIFLUOROMETHANE & FLUOROTRICHLOROMETHANE CAN
CAUSE/AGGRAVATE AN IRREGULAR HEARTBEAT. FOR RESUSCITATION,
EPINEPHRINE & SIMILAR DRUG SHOULD B E USED W/CAUTION.

Extinguishing Media:WATER SPRAY, MULTI-PURPOSE DRY CHEMICAL
Fire Fighting Procedures:WEAR FULL PROTECTIVE CLOTHING & SELF CONTAINED
BREATHING APPARATUS.
Unusual Fire/Explosion Hazard:CANISTERS EXPOSED TO TEMPERATURES ABOVE
120F MAY RUPTURE & CAUSE INJURY/DEATH.

Spill Release Procedures:COLLECT LEAK, TRANSFER TO A CLOSED WASTE
CONTAINER FOR DISPOSAL. FOR LARGE/BULK QUANTITIES: COLLECT BY
SWEEPING/WIPING & PLACE IN A LABELED SEALED CONTAINER FOR
DISPOSAL.WASH AREA W/SUITABLE CLEANING SOLVENT. IF CANISTER
LEAKAGE, FREON-12/FREON-11 WILL EVAPORATE, BUT THESE SUBSTANCES MAY
HARM THE ENVIRONMENT BY DEPLETING OZONE IN THE UPPER ATOMOSPHERE.

Handling and Storage Precautions:STORE BETWEEN 59 & 86F. DON'T
PUNCTURE. DON'T USE/STORE NEAR HEAT/OPEN FLAME.
Other Precautions:CONTENTS OF VENTOLIN INHALATION AEROSOL ARE UNDER
PRESSURE. NEVER THROW PRESSURIZED CONTAINER INTO AN INCINERATOR.
DON'T PUNCTURE.

Respiratory Protection:REQUIRED BY NIOSH, ANSI FOR RESPIRATORY
PROTECTION FOR EXPOSURE TO AIRBORNE CONCENTRATIONS ABOVE THE OEL.
Ventilation:GOOD GENERAL EXHAUST TO KEEP AIRBORNE CONCENTRATIONS BELOW
THE OEL.
Protective Gloves:REQUIRED
Eye Protection:REQUIRED
Other Protective Equipment:ADEQUATE CLOTHING TO PREVENT SKIN CONTACT.
Work Hygienic Practices:WASH HANDS THOROUGHLY AFTER HANDLING THIS
MATERIAL.SPECIAL CARE SHOULD BE TAKEN TO ENSURE THAT CONTAMINATED
CLOTHING & EQUIPMENT IS PROPERLY CLEANED AFTER USE
Supplemental Safety and Health
APPEARANCE/ODOR: FREON-12: COLORLESS GAS W/ETHER-LIKE ODOR. FREON-11:
COLORLESS & ODORLESS GAS. ALBUTEROL IS A BETA-2-ADRENERGIC
BRONCHODILATOR USED FOR BRONCHIAL SMOOTH MUSCLE RELAXATION. USED
FOR PR EVENTION/RELIEF OF BRONCHOSPASM IN PATIENTS W/REVERSIBLE
OBSTRUCTIVE AIRWAY DISEASE.

Boiling Pt:B.P. Text:FREON12:-22F/FREON11:Melt/Freeze Pt:M.P/F.P
Text:303-316F ALBUTEROL
Vapor Pres:FREON12: >76/FREON11: 69
Solubility in Water:1.5% W/V IN WATER
Appearance and Odor:ODORLESS, WHITE CRYSTALLINE POWDER W/SLIGHT BITTER
TASTE. SEE SUPP DATA.

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:THERMAL DECOMPOSITION PRODUCTS OF
ALBUTEROL: THE ACTIVE INGREDIENT IN VENTOLIN, INCLUDE TOXIC &
CORROSIVE OXIDES OF NITROGEN.

Waste Disposal Methods:PROPELLANTS SHOULD BE REMOVED FROM CANISTERS &
RECYCLED. UNUSED PRODUCT & SPENT CANISTERS SHOULD BE DISPOSED OF AT
AN APPROVED FACILITY/DISPOSE OF IN ACCORDANCE W/LOCAL, STATE &
FEDERAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Transport Information:DOT PROPER SHIPPING NAME: CONSUMER COMMODITY.
ORM-D. MEDICINES IN SMALL INNER PACKAGINGS. MAX NET QTY PER
PACKAGE: 25 KG GROSS.