Product ID:TUNICAMYCIN, STREPTOMYCES LYSOSUPERFICUS, 654380
MSDS Date:01/28/1999
FSC:6550
NIIN:00N092497
Status Code:A
MSDS Number: CJSPL

Emergency Phone: 800-424-9300 (CHEMTREC)

Info Phone: 800-854-3417

Cage: 29089

Telephone: 619-450-5558; 800-854-3417

Cage: 29089

TUNICAMYCIN

CAS: 11089-65-9

RTECS: YO7980200

OSHA PEL N/K

ACGIH TLV: N/K

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL OR FATAL BY
INGESTION, INHALATION OR ABSORPTION THROUGH SKIN. MATERIAL MAY
CAUSE MICROSCOPIC LIVER DAMAGE AND DECREASED LIVER ENZYME ACTIVITY.
CHRONIC: THERE IS LIMITED EVIDENCE THAT TUNICAMYCIN IS TERATOGENIC
IN LABORATORY ANIMALS. THERE IS ALSO LIMITED EVIDENCE THAT
TUNICAMYCIN IS MUTAGENIC IN LABORATORY CELL CULTURES. UNTIL FURTHER
TESTING HAS BEEN DONE, IT SHOULD BE TREAT ED AS A POSSIBLE
TERATOGEN AND MUTAGEN IN HUMANS.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:SKIN: WASH WITH SOAP AND COPIOUS AMOUNTS OF WATER FOR AT
LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES AND WASH
BEFORE WEARING. CONSULT A PHYSICIAN. EYES: FLUSH WITH COPIOUS
AMOUNTS OF WATE R FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING
BY SEPARATING THE EYELIDS WITH FINGERS. CONSULT A PHYSICIAN.
INHALATION: REMOVE TO FRESH AIR AND MONITOR BREATHING. IF BREATHING
BECOMES DIFFICULT, GIVE OXYGEN AND CONSULT A PHYSICIAN. IF
BREATHING STOPS, GIVE ARTIFICIAL RESPIRATION AND CONSULT A
PHYSICIAN. INGESTION: WASH MOUTH OUT WITH WATER AND CONSULT THE
LOCAL POISON CENTER AND A PHYSICIAN.

Extinguishing Media:DRY CHEMICAL POWDER, CARBON DIOXIDE, ALCOHOL OR
POLYMER FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:UPON THERMAL DECOMPOSITION, IT MAY EMIT
TOXIC GASES.

Spill Release Procedures:EVACUATE AREA. WEAR A NIOSH APPROVED
SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS, AND HEAVY RUBBER
GLOVES. SWEEP UP AND PLACE IN A SUITABLE CONTAINER. AVOID RAISING
DUST. HOLD FOR APPROPRIATE DIS POSAL. WASH SPILL SITE AND VENTILATE
AREA AFTER MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:STORE IN A TIGHTLY CLOSED CONTAINER IN
A COOL, DRY PLACE (+20C). POSSIBLE TERATOGEN AND MUTAGEN. AVOID
CONTACT WITH MATERIAL. AVOID PROLONGED OR REPEATED EXPOSURE. LAB
SHOULD BE EQUIPPED WITH A SAFETY SHOWER AND AN EYE WASH STATION.
WASH THOROUGHLY AFTER HANDLING MATERIAL.
Other Precautions:MATERIAL SHOULD ONLY BE HANDLED BY QUALIFIED,
EXPERIENCED PROFESSIONALS.

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR.
Ventilation:HANDLE IN A CHEMICAL FUME HOOD WITH ADEQUATE VENTILATION.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EMERGENCY EYEWASH AND DELUGE
SHOWER .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
PHYSICAL/CHEMICAL PROPERTIES: SOLUBILITY: SOLUBLE IN DMF, DMSO AND
PYRIDINE.

Melt/Freeze Pt:>234.C, 453.2F
M.P/F.P Text:234C - 235C
Appearance and Odor:SOLID.

Stability Indicator/Materials to Avoid:YES
AVOID CONTACT WITH STRONG OXIDIZING AGENTS.
Stability Condition to Avoid:STABLE UNDER NORMAL HANDLING PROCEDURES.
Hazardous Decomposition Products:UPON THERMAL DECOMPOSITION, MAY EMIT
TOXIC GASES INCLUDING CARBON MONOXIDE, CARBON DIOXIDE, AND NITROGEN
OXIDES.

Waste Disposal Methods:COUNTRY, FEDERAL, STATE, & LOCAL REGULATIONS ARE
VARIED & CHANGE FREQUENTLY. FOR THIS REASON, MANUFACTURER
RECOMMENDS THAT YOU CONTACT YOUR LOCAL DEPARTMENT OF HEALTH
SERVICES FOR INFORMATION ON THE D ISPOSAL OF THIS PRODUCT/ARRANGE
FOR DISPOSAL BY A LICENSED DISPOSAL COMPANY. DISPOSE OF IN
ACCORDANC E WITH LOCAL, STATE, & FEDERAL REGULATIONS .

Toxicological Information:RTECS NUMBER: YO7980200. REPRODUCTIVE EFFECTS
AND REFERENCES: PAR; MUS; DOSE: 500 UG/KG ABORTION 1983.
TERATOLOGY, THE INTERNATIONAL JOURNAL OF ABNORMAL DEVELOPMENT. 28,
13A. GENETIC DATA AND REFERENC ES: OTH; MUS; DOSE: 4 UG/L DNA
INHIBITION 1986. JOURNAL OF ANTIBIOTICS. 39, 1148. REFER TO THE
REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) FOR A
DEFINITION OF ABBREVIATIONS USED IN THE AB OVE TEXT AND FOR
ADDITIONAL INFORMATION. THIS REPORT CONTAINS ONLY SELECTED
INFORMATION FROM THE RTECS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:NO INFORMATION AVAILABLE.

Transport Information:UN NUMBER: UN3172. PROPER SHIPPING NAME: TOXINS,
SOLID, EXTRACTED FROM LIVING SOURCES, N.O.S. IATA CLASS: 6.1. IATA
PACKING GROUP: III.

Federal Regulatory Information:T+. RISK PHRASES: R26/27/28: VERY TOXIC
BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED. R40: POSSIBLE
RISK OF IRREVERSIBLE EFFECTS. SAFETY PHRASES: S22: DO NOT BREATHE
DUST. S24/25: AVOID CONTAC T WITH SKIN AND EYES. S36/37/39: WEAR
SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION. S45:
IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
IMMEDIATELY.