Product ID:FORMAMIDE MOLECULAR BIOLOGY REAGENT, F7508
MSDS Date:01/01/1999
FSC:6810
NIIN:00N092605
Status Code:A
MSDS Number: CJTRS

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

FORMAMIDE

CAS: 75-12-7

RTECS: LQ0525000

ACGIH TLV: 18 MG/M3;10 PPM

LD50 LC50 Mixture:LD50 (ORAL, RAT): 5577 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INHALATION,
INGESTION, OR SKIN ABSORPTION. CAUSES SEVERE EYE IRRITAITON. CAUSES
SKIN IRRITAITON. MATERIAL CAN CAUSE SEVERE BURNS AND BLISTERING
WHICH MAY NOT BE IMMEDIATELY PA INFUL OR VISIBLE. THE FULL EXTENT
OF TISSUE DAMAGE MAY NOT EXHIBIT ITSELF FOR 12-24 HOURS AFTER
EXPOSURE. EXPOSURE CAN CAUSE: GASTROINTESTINAL DISTURBANCES.
READILY ABSORBED THROUGH SKIN. CHRONIC: MAY CAUSE CONGENITAL
MALFORMATION IN THE FETUS. TARGET ORGAN (S): BLOOD, CENTRAL NERVOUS
SYSTEM, LIVER, AND KIDNEYS.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:EYES OR SKIN: IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING
CONTAMINATED CLOTHING AND SHOES. ASSURE ADEQUATE FLUSHING OF THE
EYES BY SEPARATING TH E EYELIDS WITH FINGERS. INHALATION: REMOVE TO
FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF
BREATHING IS DIFFICULT, GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH
WATER PROVIDED PERSON IS C ONSCIOUS. CALL A PHYSICIAN. WASH
CONTAMINATED CLOTHING BEFORE REUSE.

Flash Point:=154.4C, 310.F
Autoignition Temp:=500.C, 932.F
Extinguishing Media:WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA & FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS, RUBBER BOOTS AND HEAVY RUBBER GLOVES. EVACUATE AREA
ABSORB ON SAND OR VERMICULITE AND PLACE IN CLOSED CONTAINERS FOR
DISPOSAL. VENTILATE AREA AN D WASH SPILL SITE AFTER MATERIAL PICKUP
IS COMPLETE.

Handling and Storage Precautions:DO NOT BREATHE VAPOR. DO NOT GET IN
EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.
KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE.

Respiratory Protection:NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYE WASH AND DELUGE SHOWER MEETING ANSI
DESIGN CRITERIA .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

Boiling Pt:=210.C, 410.F
Melt/Freeze Pt:>2.C, 35.6F
Vapor Pres:0.08MM 20C - 30MM 129C
Vapor Density:1.55
Spec Gravity:1.134
Appearance and Odor:COLORLESS LIQUID.

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS, PROTECT FROM MOISTURE, ACIDS, BASES.
Stability Condition to Avoid:KEEP AWAY FROM HEAT, SPARKS, AND OPEN
FLAME.
Hazardous Decomposition Products:TOXIC FUMES OF: CARBON MONOXIDE,
CARBON DIOXIDE, NITROGEN OXIDES.
Conditions to Avoid Polymerization:WILL NOT OCCUR.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDEERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.

Toxicological Information:TO THE BEST OF MFR'S KNOWLEDGE, THE CHEMICAL,
PHYSICAL, AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY
INVESTIGATED. RTECS #: LQ0525000 FORMAMIDE. IRRITATION DATA:
EYE-RBT 100 MG SEV AJOPAA 29, 1363,1946. TOXICITY DATA: ORL-RAT
LD50:5577 MG/KG TPKVAL 9,163,1967. IPR-RAT LD50:5700 MG/KG TXAPA9
26,596,1973. SCU-RAT LD50:>4 GM/KG APEPA2 257,296,1967. UNR-RAT
LD50:3 GM/KG EXPEAM 29,225,1973. ORL -MUS LD50:3150 MG/KG TPKVAL
11,86,1969. IPR-MUS LD50:2450 MG/KG AEPPAE 230,559,1957. IPR-GPG
LD50:1250 MG/KG TPKVAL 9,163,1967. ORL-MAM LD50:3150 MG/KG GISAAA
39 (4), 86,1974. TARGET ORGAN DATA: (ECOL OGICAL INFORMATION)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE. --TOXICOLOGICAL INFO: AUTONOMIC
NERVOUS SYTEM (OTHER: PARASYMPATHOMIMETIC). BEHAVIOR (SOMNOLENCE,
CONVULSION OR EFFECT ON SEIZURE THRESHOLD). EFFECTS ON FERTILITY
(POST-IMPLANT ATION MORTALITY). EFFECTS ON EMBRYO OR FETUS
(FETOTOXICITY, FETAL DEATH). SPECIFIC DEVELOPMENTAL ABNORMALITIES
(MUSCULOSKELETAL SYSTEM). ONLY SELECTED REGISTRY OF TOXIC EFFECTS
OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL
ENTRY IN RTECS FOR COMPLETE INFORMATION.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

SARA Title III Information:REVIEWS, STANDARDS, AND REGULATIONS: OEL=MAK
ACGIH TLV-TWA 18 MG/M3 (10 PPM) (SKIN) DTLVS* TLV/BEI,1997.
OEL-AUSTRALIA:TWA 10 PPM (15 MG/M3); SKIN JAN 1993. OEL-BELGIUM:TWA
10 PPM (18 MG/M3); SKIN JAN 1993. OEL-DENMARK:TWA 20 PPM (30
MG/M3) JAN 1993. OEL-FINLAND:TWA 20 PPM (37 MG/M3); STEL 30 PPM (55
MG/M3); SKIN JAN 1993. OEL-FRANCE:TWA 20 PPM (30 MG/M3) JAN 1993.
OEL-THE NETHERLANDS: TWA 20 PPM (30 MG/M3) JAN 1993.
OEL-RUSSIA:STEL 3 MG/M3 JAN 1993. OEL-SWITZERLAND: TWA 20 PPM (37
MG/M3) JAN 1993. OEL-UNITED KINGDOM:TWA 20 PM (30 MG/M3); STEL 30
PPM (45 MG/M3) JAN 1993. OEL IN BULGARIA, COLOM BIA, JORDAN, KOREA
(REGULATORY STATE)
Federal Regulatory Information:EUROPEAN INFORMATION: TOXIC R 61 MAY
CAUSE HARM TO THE UNBORN CHILD. R 41 RISK OF SERIOUS DAMAGE TO
EYES. R 37/38 IRRITATING TO RESPIRATORY SYSTEM AND SKIN. S 45 IN
CASE OF ACCIDENT OR IF YOU FEEL UNW ELL, SEEK MEDICAL ADVICE
IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE). S 26 IN CASE OF
CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF WATER AND SEEK
MEDICAL ADVICE. S 36/37/39 WEAR SUITABLE PROTEC TIVE CLOTHING,
GLOVES AND EYE/FACE PROTECTION. S 23 DO NOT BREATHE VAPOR.
State Regulatory Information:N/P --SARA TITLE III: CHECK ACGIH TLV. OEL
IN NEW ZEALAND, SINGAPORE, VIETAM CHECK ACGIH TLV. NIOSH REL TO
FORMAMIDE-AIR:10H TWA 10 PPM (SK). NIOSH* DHHS #92-100,1992. NOHS
1974: HZD 84454; NIS 6; TNF 227; NOS 14; TNE 3195. NOES 1983: HZD
84454; NIS 3; TNF 42; NOS 5; TNE 2724; TFE 556. EPA GENETOX PROGRAM
1988, NEGATIVE: CELL TRANSFORM. -RLV F344 RAT EMBRYO. EPA TSCA
SECTION 8(B) CHEMICAL INVENTOR Y. EPA TSCA 8(A) PRELIMINARY
ASSESSMENT INFORMATION, FINAL RULE FERECA 47,26992,82. EPA TSCA
SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES. EPA TSCA TEST
SUBMISSION (TSCATS) DATA BASE, JUNE 1998. (OTHER INFORMATION)