Product ID:L-TRYPTOPHAN, T0254
MSDS Date:07/01/1999
FSC:6505
NIIN:00N092739
Status Code:A
MSDS Number: CJTTS

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

L-TRYPOTHAN

CAS: 73-22-3

RTECS: YN6130000

LD50 LC50 Mixture:LD50 (ORAL, RAT): >16 GM/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INHALATION,
INGESTION, OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE
SKIN IRRITATION. THE FOOD AND DRUG ADMINISTRATION AND THE CENTER
FOR DISEASE CONTROL HAVE ESTABL ISHED A LINK BETWEEN L-TRYPTOPHAN
AND A SOMETIME FATAL BLOOD DISORDER CALLED EOSINOPHILIA-MYALGIA
SYNDROME WHICH IS MARKED BY SEVERE MUSCLE AND JOINT PAIN, SWELLING
OF THE ARMS AND LEGS, SKIN RASH AND SOMETIMES FEVER. IT IS
CHARACTERIZED BY SEVERE EOSINOPHILLIA, A BLOOD DISORDER IN WHICH
THE WHITE BLOOD CELLS INCREASE TO AN ABNORMALLY HIGH LEVEL.
L-TRYPTOPHAN OCURS NATURALLY IN MANY FOODS AND INVE STIGATION HAS
NOT (EFTS OF OVEREXP)
Effects of Overexposure:HLTH HAZ: ESTABLISHED WHETHER IT OR AN IMPURITY
INTRODUCED DURING MANUFACTURE OR DISTRIBUTION IS THE CAUSE.

First Aid:EYES: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT
LEAST 15 MINUTES. SKIN: IMMEDIATELY WASH WITH SOAP AND COPIOUS
AMOUNTS OF WATER. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING
GIVE ART IFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE
OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS
CONSCIOUS. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE
REUSE.

Extinguishing Media:WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA & FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES,
RUBBER BOOTS AND HEAVY RUBBER GLOVES. SPILL MATERIAL SHOULD BE
CAREFULLY WIPED UP OR MOISTENED WITH WATER AND REMOVED. VENTILATE
AREA AND WASH SPILL SITE AFTE R MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:AVOID INHALATION. AVOID CONTACT WITH
EYES, SKIN AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. KEEP
TIGHTLY CLOSED. STORE IN COOL DRY PLACE.

Respiratory Protection:NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:COMPATIBLE CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYE WASH AND DELUGE SHOWER MEETING ANSI
DESIGN CRITERIA .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

Melt/Freeze Pt:>280.C, 536.F
M.P/F.P Text:280-285C
Appearance and Odor:SOLID.

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS.
Hazardous Decomposition Products:HAZARDOUS COMBUSTION OR DECOMPOSITION
PRODUCTS TOXIC FUMES OF: CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN
OXIDES.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.

Toxicological Information:RTECS #: YN6130000 TRYPTOPHAN, L- TOXICITY
DATA: ORL-RAT LD50:>16 GM/KG IYKEDH 11,635,1980. IPR-RAT LD50:1634
MG/KG ABBIA4 58,253,1955. IPR-MUS LD50:4800 MG/KG IYKEDH
11,635,1980. IPR-BRD LD50:2410 MG /KG NIIRDN -, 744,1990. TARGET
ORGAN DATA: BEHAVIORAL (EXCITEMENT). BEHAVIORAL (ANTIANXIETY).
LUNGS, THORAX/ RESP (DYSPNAE). KIDNEY, URETER, BLADDER (BLADDER
TUMORS). BLOOD (EOSINOPHILIA). MUSCULO-SKE LETAL (OTHER CHANGES).
SKIN AND APPENDAGES (OTHER GLANDS). MATERNAL EFFECTS (OVARIES,
FALLOPIAN TUBES). EFFECTS ON EMBRYO OR FETUS (MATERNAL-FETAL
EXHANGE). EFFECTS ON NEWBORN (DELAYED EFFECTS). (OTHE R INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

Federal Regulatory Information:REVIEWS, STANDARDS, AND REGULATIONS:
OEL=MAK. NOES 1983: HZD X3075; NIS 6; TNF 1257; NOS 19; TNE 24809;
TFE 18622. EPA TSCA SECTION 8 (B) CHEMICAL INVENTORY. NCI
CARCINOGENESIS BIOASSAY (FEED); NO EVI DENCE: MOUSE, RAT NCITR*
NCI-TR-71,78.