Product ID:METHANESULFONIC ACID ETHYL ESTER, M0880
MSDS Date:01/01/1999
FSC:6505
NIIN:00N092665
Status Code:A
MSDS Number: CJVMK

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

METHANESULFONIC ACID ETHYL ESTER

CAS: 62-50-0

RTECS: PB2100000

OSHA PEL N/K

ACGIH TLV: N/K

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:YES IARC:YES OSHA:NO
Health Hazards Acute and Chronic:ACUTE: HARMFUL IF SWALLOWED, INHALED,
OR ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION. CHRONIC:
CARCINOGEN. MAY ALTER GENETIC MATERIAL. TARGET ORGANS: LUNGS,
KIDNEYS.
Explanation of Carcinogenicity:METHANESULFONIC ACID ETHYL ESTER: IARC
MONOGRAPHS, SUPPLEMENT, VOLUME 7, PAGE 56, 1987: GROUP 2B. NTP 8TH
ANNUAL REPORT ON CARCINOGENS, 1998: REASONABLY ANTICIPATED TO BE
HUMAN CARCINOGEN.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES, WHILE REMOVING CONTAMINATED CLOTHING AND
SHOES. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE
ARTIFICIAL R ESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.

Flash Point:=100.C, 212.F
Extinguishing Media:WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS AND FULL PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:EVACUATE AREA. WEAR NIOSH APPROVED SCBA,
RUBBER BOOTS AND HEAVY RUBBER GLOVES. WEAR DISPOSABLE COVERALLS AND
DISCARD THEM AFTER USE. COVER WITH DRY LIME OR SODA ASH, PICK UP,
KEEP IN A CLOSED CONTAINE R AND HOLD FOR WASTE DISPOSAL. VENTILATE
AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:DO NOT BREATHE VAPOR. AVOID ALL
CONTACT. TOXIC. CARCINOGEN. MUTAGEN. HARMFUL LIQ & FUMES. KEEP
TIGHTLY CLOSED. STORE IN COOL DRY PLACE. LABEL PREC STATEMENTS:
TOXIC. MAY CAUSE CANCER. MAY CAUSE HERITA BLE GENETIC DMG. HARMFUL
BY INHAL, IN CONT W/SKIN & IF SWALLOWED. TARGET ORGAN(S): LUNGS,
KIDNEYS.
Other Precautions:IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK
MEDICAL ADVICE IMMEDIATELY (SHOW LABEL WHERE POSSIBLE). WEAR
SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION. DO
NOT BREATHE VAPOR. INGREDI ENT INFORMATION: MF: C*3H*8O*3S. EC NO:
200-536-7.

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EMERGENCY EYEWASH AND DELUGE
SHOWER . WEAR OTHER PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
TOX INFO: SPECIFIC DEVEL ABNORMS (CRANIOFACIAL, MUSCOLESKETAL SYS,
OTHER DEVEL ABNORMS); TUMORIGENIC EFTS (TRANSPLACENTAL
TUMORIGENESIS); EFTS ON NEWBORN (LIVE BIRTH INDEX, GERM CELL EFTS,
DELAYED EFT S); TUMORIGENIC (CARCIN BY RTECS CRITERIA, NEOPLASTIC
BY RTECS CRITERIA, EQUIVOCAL TUMORIGENIC AGENT BY (OTHER INFO)

Boiling Pt:>85.C, 185.F
B.P. Text:85C - 86C/10MM
Spec Gravity:1.167
Appearance and Odor:COLORLESS TO YELLOW LIQUID.

STRONG OXIDIZING AGENTS, STRONG BASES.
Hazardous Decomposition Products:TOXIC FUMES OF CARBON MONOXIDE, CARBON
DIOXIDE, SULFUR OXIDES.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS. RC RA WASTE NUMBER U119.

Toxicological Information:RTECS #: PB2100000-METHANESULFONIC ACID,
ETHYL ESTER. TOXICITY DATA: IPR-RAT LD50: 350 MG/KG; CPBTAL 8, 807,
1960. ORL-MUS LD50: 470 MG/KG; MUREAV 223, 373, 1989. IPR-MUS LD50:
435 MG/KG; CBINA8 3, 11 7, 1971. TARGET ORGAN DATA: BRAIN &
COVERINGS (TUMORS); LUNGS, THORAX/RESP (TUMORS); KIDNEY, URETER,
BLADDER (KIDNEY TUMORS); SKIN & APPENDAGES (TUMORS); PATERNAL EFTS
(SPERMATOGENESIS, TESTES, EPIDID YMIS, SPERM DUCT); EFTS ON
FERTILITY (MATING PERFORMANCE, MALE FERTILITY INDEX,
PRE-IMPLANTATION MORTALITY, POST-IMPLANTATION MORTALITY, LITTER
SIZE); EFTS ON EMBRYO/FETUS (FETOTOXICITY, FETAL DEATH, OTHER EFTS
TO EMBRYO/FETUS); (SUP DAT)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE. --OTHER INFO: POS: MAMMALIAN
MICRONUCLEUS; POS: IN VITRO HUMAN LYMPHOCYTE MICRONUCLEUS, MOUSE
SPOT TEST; POS: N CRASSA-FORWARD MUTATION, N CRASSA-REVERSION; POS:
E COLI POLA W/ OUT S9, IN VITRO SCE-HUMAN LYMPHOCYTES; POS: MOUSE
SPECIFIC LOCUS, SPERM MORPHOLOGY-MOUSE F1; POS: SPERM
MORPHOLOGY-MOUSE, D MELANOGASTER SEX-LINKED LETHAL; POS: UDS IN
MOUSE GERM CELLS, V79 CELL CULT URE-GENE MUTATION; POS: TRP
REVERSION, S CEREVISIAE GENE CONVERSION; POS: S CEREVISIAE-FORWARD
MUTATION, S CEREVISIAE-HOMOZYGOSIS; POS: S CEREVISIAE-ANEUPLOIDY, S
CEREVISIAE-REVERSION; (TRANSPORT INFO )

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORATION
INFORMATION. --ECOLOGICAL INFO: POS: S POMBE-FORWARD MUTATION, S
POMBE-REVERSION; POS/DOSE RESPONSE: RODENT DOMINANT LETHAL;
POS/DOSE RESPONSE: RODENT HERITABLE TRANSLOCATION; POS/DOSE
RESPONSE: IN VITRO SCE-HUMAN, IN VITRO SCE-NONHUMAN; POS/DOSE
RESPONSE: IN VIVO SCE-NONHUMAN; POS/DOSE RESPONSE: IN VITRO
UDS-HUMAN FIBROBLAST; NEG: N CRASSA-ANEUPLOI DY; INCONCLUSIVE:
CYTOGENETICS-MALE GERM CELL. EPA TSCA SECTION 8 (B) CHEM INVENTORY.
EPA TSCA SECTION 8 (D) UNPUBLISHED HLTH/SFTY STUDIES. EPA TSCA TEST
SUBMISSION (TSCATS) DATA BASE, JUNE 1998. (SAR A REGS)

SARA Title III Information:N/P --TRANSPORT INFO: NTP 7TH ANNUAL REPORT
ON CARCINOGENS, 1992: ANTICIPATED TO BE CARCINOGEN.
Federal Regulatory Information:EUROPEAN INFO: TOX. R 45: MAY CAUSE
CANCER. R 46: MAY CAUSE HERITABLE GENETIC DMG. R 20/21/22: HARMFUL
BY INHAL, IN CONT W/SKIN & IF SWALLOWED. S 45: IN CASE OF
ACCIDENT/IF YOU FEEL UNWELL, SEEK MED A DVICE IMMED (SHOW LABEL
WHERE POSS). S 36/37/39: WEAR SUITABLE PROT CLTHG, GLOVES &
EYE/FACE PROT. S 23: DO NOT BREATHE VAP. REVIEWS, STDS, & REGS:
OEL=MAK. IARC CANCER REVIEW: ANIMAL SUFFICIENT EVIDE NCE; IMEMDT 7,
245, 1974. IARC CANCER REVIEW: HUMAN NO ADEQ DATA; IMEMDT 7, 245,
1974. IARC CANCER R EVIEW: GROUP 2B; IMSUDL 7, 56, 1987.
OEL-FINLAND, OEL-SWEDEN: CARCIN JAN 1993. (OTHER INFO)
State Regulatory Information:CALIFORNIA PROPOSITION 65: THIS PRODUCT IS
OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE
CANCER.