Product ID:LITHIUM CHLORIDE MOLECULAR BIOLOGY REAGENT, L9650
MSDS Date:01/01/1999
FSC:6505
NIIN:00N092667
Status Code:A
MSDS Number: CJVMN

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

(ORAL, RAT) 526 MG/KG

CAS: 7447-41-8

RTECS: OJ5950000

LD50 LC50 Mixture:SEE INGREDIENT & TOXICOLOGICAL INFO
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE EFTS: HARMFUL IF SWALLOWED,
INHALED OR ABSORBED THRU SKIN. CAUSES SEVERE SKIN IRRIT. MATL IS
IRRIT TO MUCOUS MEMBRANES & UPPER RESP TRACT. SYMPS OF EXPOS MAY
INCLUDE BURNING SENSATION, COUGHING, WHEEZING, LARYNGITIS,
SHORTNESS OF BREATH, HEADACHE, NAUSEA & VOMITING. CHRONIC EFTS: MAY
CAUSE CONGENITAL MALFORMATION IN THE FETUS. MAY CAUSE REPRODUCTIVE
DISORDERS. CYANOSIS & T-WAVE INVERSION HAV E OCCURRED IN THE
BREAST-FED INFANTS OF WOMEN RECEIVING LITHIUM CARBONATE THERAPY.
TARGET ORGANS: CENTRAL NERVOUS SYTEM, KIDNEYS, CARDIVASCULAR
SYSTEM, THYROID. TO THE BEST OF MFR'S KNOWLEDGE, THE CHE MICAL,
(EFTS OF OVEREXP)
Effects of Overexposure:HLTH HAZS: PHYSICAL & TOXICOLOGICAL PROPERTIES
HAVE NOT BEEN THOROUGHLY INVESTIGATED. ADDNL INFO: LARGE DOSES OF
LITHIUM ION HAVE CAUSED DIZZINESS & PROSTRATION & CAN CAUSE KIDNEY
DMG IF SODIUM INTAKE IS LIMITED. DEHYDRATION, WT LOSS,
DERMATOLOGICAL EFTS & THYROID DISTURBANCES HAVE BEEN REPORTED. CNS
EFTS THAT INCL SLURRED SPEECH, BLURRED VISION, SENSORY LOSS, ATAXIA
& CONVULSIONS MAY OCCUR. DIARR HEA, VOMITING & NEUROMUSCULAR EFTS
SUCH AS TREMOR, CLONUS & HYPERATICE REFLEXES MAY OCCUR AS RSLT OF
RPTD EXPOS TO LITHIUM ION. CYANOSIS & T-WAVE INVERSION HAVE
OCCURRED IN BREAST-FED INFANTS OF WOMEN RECEIVING LITHIUM
CARBONATE THERAPY.

First Aid:EYES: IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS
AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING
OF EYES BY SEPARATING THE EYELIDS WITH FINGERS. SKIN: IN CASE OF
CONTAC T, IMMEDIATELY FLUSH SKIN WITH COPIOUS AMOUNTS OF WATER FOR
AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED CLOTHING AND SHOES.
INHALATION: IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE
ARTIF ICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE REUSE.

Extinguishing Media:WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT TO PREVENT CONTACT WITH SKIN AND EYES.
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:EVACUATE AREA. WEAR NIOSH APPROVED
SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER
GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID
RAISING DUST. VENTILATE AREA AN D WASH SPILL SITE AFTER MATERIAL
PICKUP IS COMPLETE.

Handling and Storage Precautions:KEEP TIGHTLY CLOSED. STORE IN A COOL,
DRY PLACE.
Other Precautions:DO NOT BREATHE DUST. DO NOT GET IN EYES, ON SKIN, ON
CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. WASH THOROUGHLY
AFTER HANDLING.

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH AND DELUGE SHOWER .
OTHER PROTECTIVE CLOTHING.
Supplemental Safety and Health

Melt/Freeze Pt:=613.C, ######F
Appearance and Odor:SOLID.

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS. STRONG ACIDS.
Stability Condition to Avoid:PROTECT FROM MOISTURE.
Hazardous Decomposition Products:TOXIC FUMES OF: HYDROGEN CHLORIDE GAS.
LITHIUM OXIDES.

Waste Disposal Methods:CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL
SERVICE TO DISPOSE OF THIS MATERIAL. OBSERVE ALL FEDERAL, STATE AND
LOCAL ENVIRONMENTAL REGULATIONS.

Toxicological Information:RTECS #: OJ5950000 LITHIUM CHLORIDE. IRRIT
DATA: SKN-RBT 500 MG/24H SEV 28ZPAK -,7,1972. EYE-RBT 100 MG/24H
MOD 28ZPAK -,7,1972. TOXICITY DATA: ORL-HMN LDLO: 200 MG/KG/3D
JAMAAP 139,688,1949. ORL-RAT LD50: 526 MG/KG APTOA6 47,351,1980.
IPR-RAT LD50: 514 MG/KG PETKP# 22DEC1977. SCU-RAT LD50: 499 MG/KG
PETKP# 22DEC1977. ICE-RAT LD50: 4800 UG/KG PJPPAA 26,399,1974.
ORL-MUS LD50: 1165 MG/KG RPTOAN 33, 266,1970. IPR-MUS LD50: 600
MG/KG JTBIDS 6,87,1981. SCU-MUS LD50: 738 MG/KG APTOA6 43,51,1978.
IVN-MUS LD50: 363 MG/KG OYYAA2 7,413,1973. ICE-MUS LD50: 14040
UG/KG NYKZAU 69,75,1973. IPR-CAT LD50: 492 MG/KG RPTOAN
(ECOLOGICAL INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE. --TOXICOLOGICAL INFO: 42,9,1979.
ORL-RBT LD50: 800 MG/KG FATOAO 39,53,1976. ORL-QAL LD50: 422 MG/KG
AECTCV 12,355,1983. ORL-BWD LD50: 422 MG/KG AECTCV 12,355,1983.
TARGET ORGAN DATA: BRAIN & COVERINGS (RECORDINGS FROM SPECIFIC
AREAS OF CNS). SENSE ORGANS & SPECIAL SENSES (PTOSIS). BEHAVIORAL
(ALTERED SLEEP TIME). BEHAVIORAL (SOMNOLENCE). BEHAVIORAL (TREMOR).
BEHAVIORAL (FOO D INTAKE). BEHAVIORAL (MUSCLE WEAKNESS). BEHAVIORAL
(MUSCLE CONTRACTION OR SPASTICITY). BEHAVIORAL (ANTIPSYCHOTIC).
GASTROINTESTINAL (CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY
GLANDS). (TRANSPORT I NFO)

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFO. --ECOLOGICAL INFO: GASTROINTESTINAL (NAUSEA OR VOMITING).
ENDOCRINE (CHANGE IN LH). ENDOCRINE (ANDROGENIC). BLOOD (LYMPHOMA
INCLUDING HODGKIN'S DISEASE). MUSCULO-SKELETAL (OTHER CHANGES).
PATERNAL EFFECTS (SPERMATOGENESIS). PATERNAL EFFECTS (OTHER EFFECTS
ON MALE). EFFECTS ON FERTILITY (POST-IMPLANTATION MORTALITY).
EFFECTS ON FERTILITY (LITT ER SIZE). EFFECTS ON FERTILITY
(ABORTION). EFFECTS ON EMBRYO OR FETUS (FETAL DEATH). EFFECTS ON
EMBRYO OR FETUS (FETAL DEATH). EFFECTS ON EMBRYO OR FETUS (OTHER
EFFECTS TO EMBRYO OR FETUS). (SARA REG INFO)

SARA Title III Information:N/P. --TRANSPORT INFO: SPECIFIC
DEVELOPMENTAL ABNORMALITIES (EYE, EAR). SPECIFIC DEVELOPMENTAL
ABNORMALITIES (CRANIOFACIAL). EFFECTS ON NEWBORN (OTHER NEONATAL
MEASURES OR EFFECTS). EFFECTS ON NEWBORN (GROWTH STATISTICS).
EFFECTS ON NEWBORN (BIOCHEMICAL & METABOLIC). EFFECTS ON NEWBORN
(PHYSICAL). NUTRITIONAL & GROSS METABOLIC (BODY TEMPERATURE
DECREASE). TUMORIGENIC (NEOPLASTIC BY RTECS CRITERIA) . ONLY
SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS)
DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE
INFO.
Federal Regulatory Information:EUROPEAN INFO: TOXIC. R 61 MAY CAUSE
HARM TO UNBORN CHILD. R 64 MAY CAUSE HARM TO BREASTFED BABIES. R 62
POSSIBLE RISK OF IMPAIRED FERTILITY. R 22 HARMFUL IF SWALLOWED. R
36/37 IRRITATING TO EYES AND RESPIRATORY SYSTEM. S 53 AVOID
EXPOSURE - OBTAIN SPECIAL INSTRUCTIONS BEFORE USE. S 45 IN CASE OF
ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY
(SHOW THE LABEL WHERE POSSIBLE). S 36/ 37/39 WEAR SUITABLE
PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION. S 22 DO NOT
BREATHE DUST. R EVIEWS, STANDARDS & REGULATIONS: OEL=MAK. NOHS
1974: HZD 84472; NIS 26; TNF 1089; NOS 25; TNE 5881. (STATE REG
INFO)
State Regulatory Information:N/P. FED REG INFO: NOES 1983: HZD 84472;
NIS 36; TNF 2291; NOS 36; TNE 34091; TFE 15304. EPA GENETOX PROGRAM
1988, NEGATIVE: CELL TRANSFORM.-SA7/SHE; B SUBTILIS REC ASSAY. EPA
TSCA SECTION 8(B) CHEMIC AL INVENTORY.