Product ID:PAPAIN LYOPHILIZED, P4762
MSDS Date:01/01/1999
FSC:6505
NIIN:00N093124
Status Code:A
MSDS Number: CJWLC

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

PAPAIN

CAS: 9001-73-4

RTECS: RU4950000

OSHA PEL N/K

ACGIH TLV: N/K

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INHALATION,
INGESTION, OR SKIN ABSORPTION. PROLONGED OR REPEATED EXPOSURE MAY
CAUSE ALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. EXPOSURE
CAN CAUSE ASTHMA, SKIN ERUPTI ONS, EMPHYSEMA, ANAPHYLACTIC SHOCK,
AND PROTEOLYTIC ACTION.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS
CONSCIOUS. CALL A PHYSICIAN. SKIN: FLUSH WITH COPIOUS AMOUNTS OF
WATER FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
SHOES. CALL A P HYSICIAN. INHALATION: REMOVE TO FRESH AIR. IF
BREATHING BECOMES DIFFICULT, CALL A PHYSICIAN. EYES: FLUSH WITH
COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE
FLUSHING BY SEPARATING T HE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

Extinguishing Media:WATER SPRAY.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS AND FULL PROTECTIVE EQUIPMENT .

Spill Release Procedures:WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL
SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP,
PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL S ITE AFTER MATERIAL PICKUP IS
COMPLETE.

Handling and Storage Precautions:AVOID PROLONGED OR REPEATED EXPOSURE.
AVOID BREATHING DUST. KEEP CONTAINER CLOSED. USE WITH ADEQUATE
VENTILATION.

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYEWASH AND DELUGE SHOWER MEETING ANSI
DESIGN CRITERIA . PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

Solubility in Water:SOLUBLE
Appearance and Odor:TAN COARSE PARTICLES.

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:PROTECT FROM LIGHT.
Hazardous Decomposition Products:NATURE OF DECOMPOSITION PRODUCTS NOT
KNOWN.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.

Toxicological Information:RTECS # RU4950000, PAPAIN. TOXICITY DATA:
ORL-RAT LD50: >4 GM/KG; AIPTAK 159, 126, 1966. ORL-MUS LD50: 12500
MG/KG; NYKZAU 51, 27, 1955. TARGET ORGAN DATA: GI (CHANGES IN
STRUCTURE/FUNCTION OF ESOPHAG US); EFFECTS ON FERTILITY
(POST-IMPLANTATION MORTALITY); EFFECTS ON EMBRYO/FETUS (FETAL
DEATH); SPECIFIC DEVELOPMENTAL ABNORMALITIES (CNS, MUSCULOSKELETAL
SYSTEM, HEPATOBILIARY SYSTEM, UROGENITAL SYST EM, HOMEOSTASIS,
OTHER DEVELOPMENTAL ABNORMALITIES); EFFECTS OF NEWBORN
(WEANING/LACTATION INDEX). ONLY SELECTED REGISTRY OF TOXIC EFFECTS
OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE AC TUAL
ENTRY IN RTECS FOR COMPLETE INFO.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

Federal Regulatory Information:EUROPEAN INFORMATION: HARMFUL. R
36/37/38: IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN. R 42:
MAY CAUSE SENSITIZATION BY INHALATION. S 22: DO NOT BREATHE DUST. S
24: AVOID CONTACT WITH SKIN. S 26: IN CASE OF CONTACT WITH EYES,
RINSE IMMEDIATELY WITH PLENTY OF WATER AND SEEK MEDICAL ADVICE. S
36/37: WEAR SUITABLE PROTECTIVE CLOTHING AND GLOVES. REVIEWS,
STANDARDS, AND REGULATIONS: OEL=MAK. NOHS 1974: HZD 80474; NIS 28;
TNF 3537; NOS 77; TNE 46199. NOES 1983: HZD 80474; NIS 6; TNF 431;
NOS 15; TNE 8042, TFE 3088. EPA TSCA SECTION 8 (B) CHEMICAL
INVENTORY.
State Regulatory Information: