Product ID:P1585, PHORBOL 12-MYRISTATE (SUPDAT)
MSDS Date:01/01/1999
FSC:6550
NIIN:00N093173
Status Code:A
MSDS Number: CJXHC

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

PHORBOL 12-MYRISTATE 13-ACETATE, MOLECULAR BIOLOGY REAGENT

CAS: 16561-29-8

RTECS: QH4377000

Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE EFFECTS: PHORBOL ESTERS ARE SOME
OF THE MOST POTENT TUMOR PROMOTERS KNOWN TO MAN. SOME OF THE
PHORBOL ESTERS ENHANCE TUMOR PROMOTION OF KNOWN CARCINOGENS TEN
FOLD. USE EXTREME CAUTION WHEN HANDL ING THESE COMPOUNDS WITH
CARCINOGENIC COMPOUNDS. HARMFUL IF ABSORBED THROUGH THE SKIN. MAY
BE HARMFUL IF SWALLOWED. MAY BE HARMFUL IF INHALED. CAUSES SKIN
IRRITATION. MAY CAUSE EYE IRRITATION. MATERIA L MAY BE IRRITATING
TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. PHORBAL
DERIVATIVES ARE PURGATIVES IF TAKEN INTERNALLY. CHRONIC EFFECTS:
TUMOR PROMOTER. TARGET ORGAN(S): BONE MARROW. (EFTS OF OVE REXP)
Effects of Overexposure:HLTH HAZS: THE TOXICOLOGICAL PROPERTIES HAVE
NOT BEEN THOROUGHLY INVESTIGATED.

First Aid:IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS
CONSCIOUS. CALL A PHYSICIAN. IN CASE OF SKIN CONTACT, FLUSH WITH
COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. REMOVE
CONTAMINATED CLOTHI NG AND SHOES. CALL A PHYSICIAN. IF INHALED,
REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT, CALL A
PHYSICIAN. IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS
OF WATER FOR AT LEAST 15 MIN UTES. ASSURE ADEQUATE FLUSHING BY
SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

Extinguishing Media:CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE
FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:EVACUATE AREA. WEAR NIOSH APPRVD SCBA, RUBBER
BOOTS AND HEAVY RUBBER GLOVES. INACTIVATE SPILLED MATERIAL WITH 5%
SODIUM HYPOCHLORITE. ABSORB ON SAND OR VERMICULITE AND PLACE IN
CLOSED CONTAINERS FOR D ISPOSAL. VENTILATE AREA AND WASH SPILL SITE
AFTER MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:DO NOT BREATHE DUST. DO NOT GET IN
EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.
KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE.

Respiratory Protection:WEAR APPROPRIATE NIOSH-APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYE WASH & DELUGE SHOWER MEETING ANSI DESIGN
CRITERIA . OTHER PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
MFR TRADE NAME/PART NO: 13-ACETATE MOLECULAR BIOLOGY REAGENT. TOX INFO:
(NEOPLASTIC BY RTECS CRITERIA), (EQUIVOCAL TUMORIGENIC AGENT BY
RTECS CRITERIA), (TUMORS AT SITE OF APPLICATION). ONLY SELECTED
REGISTRY OF TOXIC EFTS OF CHEM SUBSTANCES (RTECS) DATA IS PRESENTED
HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFO.

Appearance and Odor:SOLID.

Stability Indicator/Materials to Avoid:YES
STRONG BASES, STRONG OXIDIZING AGENTS.
Stability Condition to Avoid:HEAT. PROTECT FROM LIGHT.
Hazardous Decomposition Products:TOXIC FUMES OF: CARBON MONOXIDE,
CARBON DIOXIDE.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.

Toxicological Information:SEE HEALTH HAZARDS. RTECS #: QH4377000.
MYRISTIC ACID, 9-ESTER W/ 1,1A-ALPHA, 1B-BETA,4,4A,7A-ALPHA,
7B,8,9,9A-DECAHYDRO-4A-BETA,
CYCLOPROPA(3,4)BENZ(1,2-E)AZULEN-5-ONE, 9A-ACETATE. IRRIT DATA:
SKN-MU S 7 NG OPEN ARTODN 44,279,1980. TOX DATA: IVN-MUS LD50:309
UG/KG AGACBH 16,535,1985. TARGET ORGAN DATA: BEHAVIORAL
(SOMNOLENCE). LUNGS, THORAX/ RESP (TUMORS). GI (TUMORS). EFTS ON
EMBRYO/ FETUS (FETOT OXICITY), (FETAL DEATH). EFTS ON NEWBORN
(GROWTH STATISTICS). NUTRITIONAL & GROSS METABOLIC (BODY TEMP
DECR). TUMORIGENIC (CARCINOGENIC BY RTECS CRITERIA), (NEOPLASTIC BY
RTECS CRITERIA) (SUPDAT)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

SARA Title III Information:FED REGULATORY INFO: EPA GENETOX PROGRAM
1988, NEGATIVE: CELL TRANSFORM.-RLV F344 RAT EMBRYO. EPA GENETOX
PROGRAM 1988, NEGATIVE: HISTIDINE REVERSION-AMES TEST. EPA GENETOX
PROGRAM 1988, NEGATIVE: V79 CELL CULTURE-GENE MUTATION; S
CEREVISIAE-HOMOZYGOSIS. EPA GENTOX PROGRAM 1988, INCONCLUSIVE: E
COLI POLA WITHOUT S9. EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE,
JUNE 1998.
Federal Regulatory Information:EUROPEAN INFORMATION. CAUTION: SUBSTANCE
NOT YET FULLY TESTED. HARMFUL R 21 HARMFUL IN CONT W/SKIN. R 38
IRRITATING TO SKIN. S 45 IN CASE OF ACCIDENT/IF YOU FEEL UNWELL,
SEEK MED ADVICE IMMED (SHOW LB L WHERE POSS). S 26 IN CASE OF CONT
W/EYES, RINSE IMMED W/PLENTY OF WATER & SEEK MED ADVICE. S 27 TAKE
OFF IMMED ALL CONTAMD CLTHG. S 36/3739 WEAR SUITABLE PROT CLTHG,
GLOVES & EYE/FACE PROT. REVIEWS, STDS, & REGS. OEL=MAK. EPA
GENETOX PROGRAM 1988, POSITIVE: IN VITRO SCE-NONHUMAN. EPA GENETOX
PROGR AM 1988, NEGATIVE: SHE-CLONAL ASSAY; CELL
TRANSFORM.-C3H/10T1/2. (SARA TITLE III).