Product ID:MITOMYCIN C FROM STREPTOMYCES CAESPITOSUS, M0503
MSDS Date:01/01/1999
FSC:6505
NIIN:00N093130
Status Code:A
MSDS Number: CJXKW

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

200-008-6.

CAS: 50-07-7

RTECS: CN0700000

OSHA PEL N/K

ACGIH TLV: N/K

EPA Report Quantity: 10 LBS

DOT Report Quantity: 10 LBS

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:YES OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE FATAL IF INHALED,
SWALLOWED, OR ABSORBED THROUGH SKIN. CAUSES EYE AND SKIN
IRRITATION. MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT. CHRONIC: CARCINOGEN. MAY AL TER GENETIC
MATERIAL. OVEREXPOSURE MAY CAUSE REPRODUCTIVE DISORDERS BASED ON
TESTS WITH LABORATORY ANIMALS. TARGET ORGANS: BONE MARROW, LIVER.
Explanation of Carcinogenicity:MITOMYCIN: IARC MONOGRAPHS, SUPPLEMENT,
VOLUME 7, PAGE 56, 1987: GROUP 2B.
Effects of Overexposure:SEE HEALTH HAZARDS. -- OTHER INFORMATION:
NUTRITIONAL AND GROSS METABOLIC (WEIGHT LOSS OR DECREASED WEIGHT
GAIN); TUMORIGENIC (CARCINOGENIC BY RTECS CRITERIA, NEOPLASTIC BY
RTECS CRITERIA, TUMORS AT S ITE OF APPLICATION). ONLY SELECTED
REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS
PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION.

First Aid:EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES, WHILE REMOVING CONTAMINATED CLOTHING AND
SHOES. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE
ARTIFICIAL R ESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE REUSE.

Extinguishing Media:WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS AND FULL PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:EVACUATE AREA. SHUT OFF ALL SOURCES OF
IGNITION. WEAR NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS,
RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND
HOLD FOR WASTE DISPOSAL. AVO ID RAISING DUST. VENTILATE AREA AND
WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:DO NOT BREATHE DUST. DO NOT GET IN
EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.
CARCINOGEN. HIGHLY TOXIC. MUTAGEN. POSSIBLE TERATOGEN. IRRITANT.
KEEP TIGHLY CLOSED.

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EMERGENCY EYEWASH AND DELUGE
SHOWER . PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
EC #: 200-008-6. TOX INFO: NIIRDN -, 1129, 1990. IVN-RBT LD50: 3400
UG/KG; NIIRDN -, 1129, 1990. ORL-QAL LD50: >100 MG/KG; EESADV 6,
149, 1982. ORL-BWD LD50: 7500 UG/KG; AECTCV 12, 355, 1983. TARGET O
RGAN DATA: BEHAVIORAL (SOMNOLENCE, ATAXIA); LUNGS, THORAX/RESP
(FIBROSING ALVEOLITIS, DYSPNAE); (OTHER INFO)

Appearance and Odor:SOLID.

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS, STRONG ACIDS, STRONG BASES.
Hazardous Decomposition Products:TOXIC FUMES OF CARBON MONOXIDE, CARBON
DIOXIDE, NITROGEN OXIDES.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS. RC RA WASTE NUMBER U010.

Toxicological Information:RTECS # CN0700000 - AZIRINO (2', 3': 3, 4)
PYRROLO (1, 2-A) INDOLE-4, 7-DIONE, 6-AMINO-1, 1A, 2, 8, 8A,
8B-HEXAHYDRO-8-(HYDROXY METHYL)-8A-METHOXY-5-METHYL-, CARBAMATE
(ESTER). TOX DATA: ORL-RAT LD50: 30 MG/KG; CNREA8 20, 1354, 1960.
IPR-RAT LD50: 2 MG/KG; ADTEAS 3, 181, 1968. SCU-RAT LD50: 3250
UG/KG; NIIRDN 6, 798, 1982. IVN-RAT LD50: 3 MG/KG; ARZNAD 20, 1467,
1970. ORL-MUS LD50: 23 MG/KG; CNREA 8 20, 1354, 1960. IPR-MUS LD50:
4 MG/KG; JAJAAA 13, 27, 1960. SCU-MUS LD50: 7300 UG/KG; JJCREP 80,
670, 1989. IVN-MUS LD50: 4 MG/KG; JAJAAA 13, 27, 1960. UNR-MUS
LD50: 12 MG/KG; CNREA8 46, 2703, 1986. IVN-DOG LD50: 720 UG/KG;
(SUP DAT)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE. -- FED REGS: IARC CANCER REVIEW:
HUMAN NO ADEQ DATA; IMEMDT 10, 171, 1976. IARC CANCER REVIEW: GROUP
2B; IMSUDL 7, 56, 1987. NOES 1983: HZD X4281; NIS 1; TNF 39; NOS 3;
TNE 108 7; TFE 588. EPA GENETOX PROGRAM 1988, POS:
CARCIN-MOUSE/RAT; IN VITRO CYTOGENETICS-NONHUMAN. EPA GENETOX
PROGRAM 1988, POS: IN VIVO CYTOGENETICS-NONHUMAN BONE MARROW. EPA
GENETOX PROGRAM 1988, POS: NI VIVO CYTOGENETICS-MAMMALIAN OOCYTE.
EPA GENETOX PROGRAM 1988, POS: CYTOGENETICS-MALE GERM CELL; RODENT
DOMINANT LETHAL. EPA GENETOX PROGRAM 1988, POS: HOST-MEDIATED
ASSAY; RODENT HERITABLE TRANSLOCAT ION. (TRANSPORT INFO)

Transport Information:CONT SIGMA CHEM COMPANY FOR TRANSPORTATION INFO.
-- ECOLOGICAL INFO: EPA GENETOX PROGRAM 1988, POS: L5178Y CELLS IN
VITRO-TK TEST; MAMMALIAN MICRONUCLEUS. EPA GENETOX PROGRAM 1988,
POS: NI VITRO HUMAN LYNPHOCYTE MICRONUCLEUS; MOUSE SPOT TEST. EPA
GENETOX PROGRAM 1988, POS: N CRASSA-FORWARD MUTATION; B SUBTILIS
REC ASSAY. EPA GENETOX PROGRAM 1988, POS: E COLI POLA W/OUT S9;
MOUSE SPECIFIC LOCUS. EP A GENETOX PROGRAM 1988, POS: SPERM
MORPHOLOGY-MOUSE; D MELANOGASTER SEX-LINKED LETHAL. EPA GENETOX
PROGRAM 1988, POS: IN VITRO UDS-HUMAN FIBROBLAST; TRP REVERSION.
EPA GENETOX PROGRAM 1988, POS: S CER EVISIAE GENE CONVERSION; (SARA
REGS)

SARA Title III Information:N/P -- TRANSPORT INFO: S
CEREVISIAE-HOMOZYGOSIS. EPA GENETOX PROGRAM 1988, POS: S
CEREVISIAE-ANEUPLOIDY; S CEREVISIAE-REVERSION. EPA GENETOX PROGRAM
1988, POS/DOSE RESPONSE: NI VITRO SCE-HUMAN LYMPHOC YTES. EPA
GENETOX PROGRAM 1988, POS/DOSE RESPONSE: IN VITRO SCE-WI-38 CELLS;
IN VITRO SCE-HUMAN. EPA GENETOX PROGRAM 1988, POS/DOSE RESPONSE: IN
VITRO SCE-NONHUMAN; IN VIVO SCE-NONHUMAN. EPA GENETOX P ROGRAM
1988, NEG: N CRASSA-ANEUPLOIDY; UDS IN MOUSE GERM CELLS. EPA
GENETOX PROGRAM 1988, NEG: TRP REVERSION. EPA GENETOX PROGRAM 1988,
INCONCLUSIVE: HISTIDINE REVERSION-AMES TEST. (STATE REGS)
Federal Regulatory Information:EUROPEAN INFO: VERY TOX. R 45: MAY CAUSE
CANCER. R 46: MAY CAUSE HERITABLE GENETIC DMG. R 26/27/28: VERY TOX
BY INHAL, IN CONT W/SKIN & IF SWALLOWED. R 36/37/38: IRRITATING TO
EYES, RESP SYS & SKIN. R 63: POSS RISK OF HARM TO UNBORN CHILD. S
45: IN CASE OF ACCIDENT/IF YOU FEEL UNWELL, SEEK MED ADVICE IMMED
(SHOW LABEL WHERE POSS). S 26: IN CASE OF CONT W/EYES, RINSE IMMED
W/PLENTY OF WATER & SEEK MED ADVICE. S 36/37/39: WEAR SUITABLE
PROT CLTHG, GLOVES & EYE/FACE PROT. S 22: DO NOT BREATHE DUST.
REVIEWS, STDS, & REGS: OEL=MAK. IARC CANCER REVIEW: ANIMAL
SUFFICIENT EVIDENCE; IMEMDT 10, 171, 1976. (ECOLOGICAL INFO)
State Regulatory Information:CALIFORNIA PROPOSITION 65: THIS PROD
IS/CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE
CANCER. -- SARA REGS: EPA GENETOX PROGRAM 1988, INCONCLUSIVE: SPERM
MORPHOLOGY-MOUSE F1.EPA GENET OX PROGRAM 1988, POS: CHO GENE
MUTATION. EPA TSCA SECTION 8 (B) CHEM INVENTORY. EPA TSCA SECTION 8
(D) UNPUBLISHED HLTH/SFTY STUDIES. EPA TSCA TEST SUBMISSION
(TSCATS) DATA BASE, JUNE 1998. NCI CARCIN OGENESIS STUDIES (IPR);
CLEAR EVIDENCE: RAT; RRCRBU 52, 1, 75. NCI CARCINOGENESIS STUDIES
(IPR); NO EVIDENCE: MOUSE; RRCRBU 52, 1, 75.