Product ID:BUFFER N3, QIAPREP 8 TURBO MINIPREP KIT: 27152, 27154
MSDS Date:11/06/1998
FSC:NIIN:Submitter:N EN
Status Code:A
MSDS Number: CKHCP

QIAGEN INC

28159 AVE STANFORD
SANTA CLARITA, CA 91355
US

Emergency Phone: 800-362-7737

Info Phone: 800-362-7737

Cage: 01QT0

QIAGEN INC

SANTA CLARITA, CA 91355 US

Telephone: 800-362-7737

Cage: 01QT0

(ORAL,RAT) 3250 MG/KG

CAS: 127-08-2

RTECS: AJ3325000

(ORAL,RAT) 3310 MG/M3

CAS: 64-19-7

RTECS: AF1225000

OSHA PEL 25 MG/M3;10 PPM

ACGIH TLV: 25 MG/M3;10 PPM

EPA Report Quantity: 5000 LBS

DOT Report Quantity: 5000 LBS

(ORAL,RAT) 475 MG/KG

CAS: 50-01-1

RTECS: MF4300000

LD50 LC50 Mixture:SEE INGREDIENTS
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: NEUTRALIZATION BUFFER N3:
AQUEOUS SOLUTION OF POTASSIUM ACETATE, ACETIC ACID, AND GUANIDINE
HYDROCHLORIDE. POTASSIUM ACETATE: MAY BE HARMFUL BY INHALATION,
INGESTION, OR SKIN ABSORPTION. MAY CA USE IRRITATION. WARNING:
HYGROSCOPIC. ACETIC ACID: HARMFUL IF SWALLOWED, INHALED, OR
ABSORBED THROUGH SKIN. MATERIAL IS DESTRUCTIVE TO TISSUE OF MUCOUS
MEMBRANES & UPPER RESPIRATORY TRACT. INHALATON MAY BE FATAL AS
RESULT OF SPASM, INFLAMMATION & EDEMA OF LARYNX & BRONCHI, CHEMICAL
PNEUMONITIS & PULMONARY EDEMA. MATERIAL IS DESTRUCTIVE TO EYES &
SKIN. WARNING: CORROSIVE, COMBUSTIBLE (EFTS OF OVER EXP)
Effects of Overexposure:HLTH HAZS: (USA DEFINITION), FLAMMABLE
(EUROPEAN DEFINITION). GUANIDINE HYDROCHLORIDE: HARMFUL IF
SWALLOWED, INHALED/ABSORBED THROUGH SKIN. CAUSES SEVERE IRRIT. HIGH
CONCS ARE EXTREMELY DESTRUCTIVE TO TISSUES OF MUC MEMB & UPPER
RESP TRACT,EYES & SKIN. SYMPS OF EXPOSURE MAY INCLUDE BURNING
SENSATION, COUGHING, WHEEZING, LARYNGITIS, SHORTNESS OF BREATH,
HEADACHE, NAUS & VOMITING. MAY CAUSE NERVOUS SYSTEM DISTURBANCES.
TARGET ORGAN(S): BONE MARROW, NERVES. WARNING: TOXIC (USA
DEFINITION) HARMFUL (EUROPEAN DEFINITION).

First Aid:EYE CONT: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR
AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING OF EYES BY SEPARATING
EYELIDS WITH FINGERS. SKIN CONT: IMMEDIATELY WASH WITH SOAP AND
COPIOU S AMOUNTS OF WATER. INHAL: REMOVE TO FRESH AIR. IF NOT
BREATHING GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT,
GIVE OXYGEN. INGEST: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS
CONSCIOUS. CA LL PHYSICIAN. REMOVE AND WASH CONTAMINATED CLOTHING
PROMPTLY.

Flash Point:=54.C, 129.2F
Extinguishing Media:NONCOMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE
TO SURROUNDING FIRE CONDITIONS.
Fire Fighting Procedures:USE NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS AND FULL PROTECTIVE EQUIPEMENT TO PREVENT CONTACT WITH
SKIN AND EYES.

Spill Release Procedures:PRECAUTIONARY MEASURES: WEAR NIOSH APPRVD
SELF-CONTAINED BREATHING APPARATUS, CHEMICAL SAFETY GOGGLES, RUBBER
BOOTS, AND HEAVY RUBBER GLOVES. CLEAN-UP PROCEDURE: ABSORB ON SAND
OR VERMICULITE AND PLAC E IN CLOSED CONTAINERS FOR DISPOSAL.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS
COMPLETE.

Handling and Storage Precautions:HARMFUL IF SWALLOWED. IRRITATING TO
EYES AND SKIN. LABELING: XN, HARMFUL, R 22-36/38. ADDITIONAL
INFORMATION: THE PRODUCT SHOULD BE HANDLED WITH THE NORMAL CAUTION
ACCORDED CHEMICALS. ADDITIONAL HARMF UL PROPERTIES CANNOT BE RULED
OUT.
Other Precautions:STORE TIGHTLY CLOSED AT 20-25C.

Respiratory Protection:NIOSH APPROVED RESPIRATOR.
Protective Gloves:RUBBER GLOVES.
Eye Protection:ANSI APPRVD CHEM WORKERS GOGG . FACESHIELD (8-INCH
MINIMUM).
Other Protective Equipment:EYE WASH & DELUGE SHOWER MEETING ANSI DESIGN
CRITERIA .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING. DO NOT GET IN
EYES, ON SKIN, ON CLOTHING.
Supplemental Safety and Health
WASTE DISP METH: PACKAGING IN SAME WAY AS SUBSTANCE ITSELF. UNLESS
SPECIFIED DIFFERENTLY, NONCONTAMINATED PACKAGING MAY BE TREATED
LIKE HOUSEHOLD WASTE OR RECYCLED. DISPOSAL MUST BE I/A/W FEDERAL,
STA TE AND LOCAL REGULATIONS .

Spec Gravity:1.14 G/CM3
pH:4.3
Solubility in Water:SOLUBLE
Appearance and Odor:COLORLESS LIQUID. CHARACTERISTIC ODOR.

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS.
Hazardous Decomposition Products:CARBON MONOXIDE, CARBON DIOXIDE,
NITROGEN OXIDE, AND HYDROGEN CHLORIDE GAS.

Waste Disposal Methods:THERE ARE NO UNIFORM REGS FOR DISP OF CHEMICALS
OR RESIDUES. CHEMICAL RESIDUE GENERALLY COUNT AS SPECIAL WASTE. WE
RECOMMEND THAT YOU CONTACT EITHER AUTHORITIES IN CHARGE OR APPRVD
WASTE DISPOSAL COMP ANIES WHICH WILL ADVISE YOU ON HOW TO DISPOSE
OF SPECIAL WASTE. HANDLE CONTAMINATED (SUPDAT)

Toxicological Information:POTASSIUM ACETATE: ORL-RAT LD50:3250 MG/KG
AIHAAP 30,470,69. ACETIC ACID: UNR-MAN LDLO: 308 MG/KG 85DCAI
2,73,70. ORL-RAT LD50:3310 MG/KG DMDJAP 31,276,59. IHL-MUS LC50:
56200 PPM/H MELAAD 48,559,57. IVN-MUS LD50:525 MG/KG APTOA6
18,141,61. SKN-RBT LD50: 1060 MG/KG UCDS 8/7/63. GUANIDINE
HYDROCHLORIDE: ORL-RAT LD50: 475 MG/KG NTIS AD-A165-747. IPR-MUS
LD50: 500 MG/KG NTIS AD277-689. ONLY SELECTED REGISTRY OF TOXIC
EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE
ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION. ACUTE EFTS:
INHAL: MAY BE HARMFUL BY INHAL. MATL IS (OTHER INFO )

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Federal Regulatory Information:LABELING: XN, HARMFUL, R 22-36/38.