Product ID:ETHYLENE GLYCOL MONOMETHYL ETHER, E5378
MSDS Date:12/01/1999
FSC:6810
NIIN:01-467-0894
Status Code:A
MSDS Number: CLHGS

Emergency Phone: 1-314-771-5765

Info Phone: 314-771-5765 / 800-325-3010

Cage: 20176

Telephone: 800-505-6275/ 314-771-5765

Cage: 1FPM8

ETHYLENE GLYCOL MONOMETHYL ETHER. (MOLECULAR FORMULA

CAS: 109-86-4

RTECS: KL5775000

OSHA PEL 80 MG/M3;25 PPM TWA

ACGIH TLV: 16 MG/M3;5 PPM

LD50 LC50 Mixture:ORAL RAT LD50 = 2370 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:CONTAINS ETHYLENE GLYCOL MONOMETHYL
ETHER WHICH APPEARS ON THE NAVY OCCUPATIONAL CHEMICAL REPRODUCTIVE
HAZARDS LIST. SEEK CONSULTATION FROM APPROPRIATE HEALTH
PROFESSIONALS CONCERNING SAFE HANDLING AN D EXPOSURE INFORMATION .
ACUTE EFFECTS: DAMAGE TO THE KIDNEYS AND LIVER. EXPOSURE CAN CAUSE:
BLOOD EFFECTS, CAUSES SKIN IRRITATION. HARMFUL IF SWALLOWED,
INHALED, OR ABSORBED THROUGH SKIN. VAP OR OR MIST IS IRRITATING TO
THE EYES, MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. MAY CAUSE
NERVOUS SYSTEM DISTURBANCES. CHRONIC EFFECTS: MAY CAUSE CONGENITAL
MALFORMATION IN THE FETUS. MAY CAUSE RE PRODUCTIVE (SYMPTOMS OF
OVEREXPOS)
Effects of Overexposure:HEALTH HAZARDS ACUTE AND CHRONIC (CON'T):
DISORDERS. TARGET ORGANS: DAMAGE TO THE KIDNEYS. DAMAGE TO THE
LIVER. BLOOD, KIDNEYS, LIVER, LUNGS, CENTRAL NERVOUS SYSTEM, MALE
REPRODUCTIVE SYSTEM, IMMUNE S YSTEM, THYMUS AND BONE MARROW. IN
LABORATORY STUDIES WITH THIS MATERIAL, BIRTH DEFECTS, FETOTOXICITY,
EMBRYOLETHALITY, ANEMIA, BONE MARROW DAMAGE, HEMOLYSIS,
IMMUNOSUPRESSION AND DAMAGE TO THE MALE R EPRODUCTIVE TISSUES HAVE
BEEN OBSERVED.

First Aid:IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH
COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING
CONTAMINATED CLOTHING AND SHOES. IF INHALED, REMOVE TO FRESH AIR.
IF NOT BREATHI NG GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS
DIFFICULT, GIVE OXYGEN. ASSURE ADEQUATE FLUSHING OF THE EYES BY
SEPARATING THE EYELIDS WITH FINGERS. INGESTION- CONTACT A PHYSICIAN
IMMEDIATELY .

Flash Point:=46.1C, 115.F
Lower Limits:2.5%
Upper Limits:24.5%
Extinguishing Media:CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE
FOAM.
Fire Fighting Procedures:WEAR NIOSH-APPROVED SELF-CONTAINED BREATHING
APPARATUS AND FULL PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN
AND EYES.
Unusual Fire/Explosion Hazard:COMBUSTIBLE LIQUID. FORMS EXPLOSIVE
MIXTURES IN AIR.

Spill Release Procedures:EVACUATE AREA. WEAR SELF-CONTAINED BREATHING
APPARATUS, RUBBER BOOTS AND HEAVY RUBBER GLOVES. ABSORB ON SAND OR
VERMICULITE AND PLACE IN CLOSED CONTAINERS FOR DISPOSAL.

Handling and Storage Precautions:USE ONLY IN A CHEMICAL FUME HOOD. KEEP
TIGHTLY CLOSED. KEEP AWAY FROM HEAT AND OPEN FLAME. STORE IN A COOL
DRY PLACE. DO NOT BREATHE VAPOR. DO NOT GET IN EYES, ON SKIN, ON
CLOTHING. AVOID PROLONGED O R REPEATED EXPOSURE.
Other Precautions:WASH THOROUGHLY AFTER HANDLING.

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL SAFETY GOGGLES AND FULL
FACESHIELD .
Other Protective Equipment:EYEWASH AND DELUGE SHOWER MEETING ANSI
DESIGN CRITERIA . WEAR OTHER PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH HANDS AFTER HANDLING.
Supplemental Safety and Health
SYNONYMS: AETHYLENGLYKOL-MONOMETHYLAETHER; DOWANOL 7; DOWANOL EM; ETHER
MONOMETHYLIQUE DE L'ETHYLENE-GLYCOL; ETHYLENE GLYCOL METHYL ETHER;
GLYCOL ETHER EM; GLYCOLMETHYL ETHER GLYCOL MONOMETHYL ETHER ;
JEFFERSON EM; 2-METHOXY-AETHANOL; METHOXYETHANOL; 2-METHOXYETHANOL
(ACGIH:OSHA); METHYL ETHOXOL; (OTHER INFORMATION)

Boiling Pt:=124.C, 255.2F
B.P. Text:124-125C
Melt/Freeze Pt:=-85.C, -121.F
Vapor Pres:6.17 MMHG
Vapor Density:2.62 G/L
Spec Gravity:0.965
Appearance and Odor:NONE SPECIFIED BY MANUFACTURER

Stability Indicator/Materials to Avoid:YES
OXIDIZING AGENTS
Hazardous Decomposition Products:CARBON MONOXIDE, CARBON DIOXIDE.

Waste Disposal Methods:THIS COMBUSTIBLE MATERIAL MAY BE BURNED IN A
CHEMICAL INCINERATOR EQUIPPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.

Toxicological Information:IN LABORATORY STUDIES WITH THIS MATERIAL,
BIRTH DEFECTS, FETOTOXICITY, EMBRYOLETHALITY, ANEMIA, BONE MARROW
DAMAGE, HEMOLYSIS, IMMUNO-SUPPRESSION AND DAMAGE TO THE MALE
REPRODUCTIVE TISSUES HAVE BEEN OBSERVED. IRRITATION DATA: SKIN-RBT
483 MG/24H MLD. EYE-RBT 97 MG; EYE-RBT 500 MG/24H MLD; EYE-GPG 10
UG MLD. TOXICITY DATA: ORAL HMN LDL0:3380 MG/KG; ORAL RAT LD50:
2370 MG/KG; IHL RAT LC50: 1500 PPM /7H; IPR RAT LD50: 2500 MG/KG;
IVN RAT LD50: 2068 MG/KG; ORL MUS LD50: 2560 MG/KG. IHL-MUS LC50:
1480 PPM/7H; IPR-MUS LD50: 2147 MG/KG; ORL-RBT LD50: 890 MG/KG;
SKN-RBT LD50: 1280 MG/KG; ORL-GPG LD50: 950 MG/KG. (SEE ECOLOGICAL
SECTION)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE. TOXICOLOGICAL (CON'T): TARGET
ORGAN DATA: BEHAVIORAL (GENERAL ANESTHETIC, TREMOR, CONVULSIONS OR
EFFECT ON SEIZURE THRESHOLD, CHANGE IN MOTOR ACTIVITY, ANALGESIA);
LUNGS, THO RAX OR RESPIRATION (DYSPNAE); GASTROINTESTINAL (OTHER
CHANGES); KIDNEY, URETER, BLADDER (HEMATURIA, OTHER CHANGES); BLOOD
(OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA); PATERNAL EFFECTS (
SPERMATOGENESIS, TESTES, EPIDIDYMIS, SPERM DUCT); MATERIAL EFFECTS
(PARTURITION); EFFECTS ON FERTILITY (FEMALE FERTILITY INDEX,
POST-IMPLANTATION MORTALITY, LITTER SIZE, ABORTION); EFFECTS ON
EMBRYO OR FETUS (FETOTOXI CITY, FETAL DEATH); (SEE TRANSPORT INFO)

Transport Information:CONTACT SIGMA CHEMICAL CO FOR TRANSPORTATION
INFORMATION. ECOLOGICAL (CON'T): SPECIFIC DEVELOPMENTAL
ABNORMALITIES (CENTRAL NERVOUS SYSTEM, CRANIOFACIAL, BODY WALL,
MUSCULOSKELETAL SYSTEM, CARDIOVAS CULAR SYSTEM, GASTROINTESTINAL
SYSTEM, UROGENITAL SYSTEM); EFFECTS ON NEWBORN (LIVE BIRTH INDEX,
VIABILITY INDEX, GROWTH STATISTICS, BIOCHEMICAL AND METABOLIC).
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.

SARA Title III Information:THIS PRODUCT IS SUBJECT TO SARA SEC 313
REPORTING REQUIREMENTS. REGULATORY INFORMATION: EUROPEAN
INFORMATION: EC INDEX NO: 603-011-00-4. FLAMMABLE. TOXIC. R 60: MAY
IMPAIR FERTILITY. R 61: MAY CAUSE HARM TO THE UNBORN CHILD. R 10:
FLAMMABLE. R 20/21/22: HARMFUL BY INHALATION, IN CONTACT WITH SKIN
AND IF SWALLOWED. S 53: AVOID EXPOSURE - OBTAIN SPECIAL
INSTRUCTIONS BEFORE USE. S 45: IN CASE OF ACC IDENT OR IF YOU FEEL
UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY (SHOW LABEL WHERE
POSSIBLE).
Federal Regulatory Information:THE INGREDIENTS OF THIS PRODUCT ARE
LISTED ON THE TSCA INVENTORY. EPA TSCA SECTION 8(B) CHEMICAL
INVENTORY. EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES.
EPA TSCA SECTION 8(E) RISK NOTIFIC ATION, 8EHQ-0892-9101. ON EPA
IRIS DATABASE. EPA TSCA TEST SUBMISSION (TSCATS) DATABASE,
SEPTEMBER 1999. NIOSH CURRENT INTELLIGENCE BULLETIN #39. NIOSH
ANALYTICAL METHOD, 1994: ALCOHOLS IV, 1403. NTP TOXICITY STUDIES,
RPT # TOX-26, SEPT 1999. OSHA ANALYTICAL METHOD #53. NIOSH REL TO
ETHYLENE GLYCO L MONOMETHYL ETHER-AIR: 10H TWA 0.1 PPM (SK), NIOSH
DHHS #92-100, 1992. CONTACT NEHC FOR ADDITIONAL INFORMATION ON
REVIEWS AND STANDARDS
State Regulatory Information:CALIFORNIA PROPOSITION 65 - THIS PRODUCT
IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO
CAUSE MALE REPRODUCTIVE TOXICITY. THIS PRODUCT IS OR CONTAINS
CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE
DEVELOPMENTAL TOXICITY. SUPP SAFETY (CON'T):
METHOXYHYDROXYETHANE; METHYL CELLOSOLVE (OSHA); METHYLCELOSOLV;
METHYL GLYCOL; METHYL OXITOL; METIL CELLOSOLVE; MONOMETHYL ETHER OF
E THYLENE GLYCOL; POLYSOL EM; PRIST; METOSSIETANOLO; METOKSYETYLOWY
ALKOHOL; METHYLGLYKOL.