Product ID:RIBAVIRIN
MSDS Date:04/27/1998
FSC:NIIN:Submitter:N EN
Status Code:A
MSDS Number: CLHKJ

Emergency Phone: 908-298-4632

Info Phone: 908-298-4632

Cage: UO117

Telephone: 908-298-4632

Cage: UO117

1-BETA-D-RIBOFURANOSYL-1 H-1, 2,

CAS: 36791-04-5

RTECS: XZ4250000

OSHA PEL NONE

ACGIH TLV: NONE

LD50 LC50 Mixture:LD50/RAT-ORAL: 5300MG/KG; MOUSE1300MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:EMERGENCY OVERVIEW: RIBAVIRIN IS AN
ANTIVIRAL AGENT, TYPICALLY INDICATED IN TREATMENT OF VIRAL
RESPIRATORY TRACT INFECTIONS. CAUTION: SUBSTANCE NOT FULLY TESTED.
MAY CAUSE HARM TO UNBORN CHILD. POT ENTIAL HEALTH EFFECTS: EYES:
MAY CAUSE IRRITATION. SKIN: MAY CAUSE IRRITATION OR SENSITIZATION.
TERATOGENICITY (BIRTH DEFECTS) RIBAVARIN IS TERATOGENIC IN SEVERAL
DIFFERENT ANIMAL SPECIES. REPRODUCTIV E EFFECTS: RIBAVARIN HAS
SHOWN TERATOGENIC EFFECTS AND OTHER ADVERSE EFFECTS ON REPRODUCTIVE
FUNCTION IN TEST ANIMALS. MUTAGENIC (GENETIC EFFECTS): THE STUDIES
FOR MUTAGENICITY IN ANIMALS ARE EQUIVOCA L. (SIGNS & SYMPTOMS OF
OVEREXPOSURE)
Effects of Overexposure:SIGNS AND SYMPTOMS OF EXPOSURE BASED ON HUMAN
EXPERIENCE INCLUDE HEADACHE AND PAIN IN EYES ON CONTACT; SKIN
IRRITATION (RASHES, REDNESS). HEALTH HAZARDS ACUTE & CHRONIC
(CONT): ACUTE INHALATION EF FECTS: ADVERSE CARDIOVASCULAR EFFECTS
INCLUDING CARDIAC ARREST, HYPOTENSION AND CARDIAC GLYCOSIDE
INTOXICATION HAVE BEEN ASSOCIATED WITH RIBAVIRIN INHALATION.
SUCHRONIC (TARGET ORGAN EFFECTS): BLOOD FORMING SYSTEMS -
RIBAVARIN AND OR ITS METABOLITES ACCUMULATE IN RED BLOOD CELLS AND
PERSIST FOR ENTENDED PERIODS FOLLOWING EXPOSURE. RIBAVARIN PRODUCES
DOSE AND TIME DEPENDENT REVERSIBLE ANEMIA, POSS IBLY RESULTING FROM
(TOXICOLOGICAL INFO)
Medical Cond Aggravated by Exposure:HYPERSENSITIVITY TO THE MATERIAL.

First Aid:EYES: FLUSH WITH WATER FOR AT LEAST 15 MINUTES. OBTAIN
MEDICAL ATTENTION. SKIN: REMOVE CONTAMINATED CLOTHING. THROUGHLY
WASH EXPOSED SKIN WITH SOAP AND WATER. OBTAIN MEDICAL ATTENTION.
INGESTION: GIVE COPIOUS AMOUNTS OF WATER AND INDUCE VOMITING, IF
CONSCIOUS. OBTAIN MEDICAL ATTENTION. INHALATION: REMOVE FROM
EXPOSURE. IF NOT BREATHING, GIVE ARTIFICIAL RESPIRATION. OBTAIN
MEDICAL ATTENTION. IN CA SE OF ACCIDENT OR IF YOU FEEL UNWELL,
SEEK MEDICAL ADVICE IMMEDIATELY.

Flash Point:N/AP F
Autoignition Temp:Autoignition Temp Text:N/AP F
Extinguishing Media:WATER, WATER SPRAY, CO2, DRY CHEMICAL.
Fire Fighting Procedures:FIGHT FIRE FROM SAFE DISTANCE OR PROTECTED
LOCATION. USE WATER SPRAY TO KEEP EXPOSED CONTAINERS AND EQUIPMENT
COOL. WEAR FULL PROTECTIVE CLOTHING AND (NIOSH APPROVED - ) SELF
CONTAINED BREATHING A PPARATUS (SCBA).
Unusual Fire/Explosion Hazard:UNDER NORMAL CONDITIONS OF USE THIS
MATERIAL DOES NOT PRESENT A SIGNIFICANT FIRE OR EXPLOSION HAZARD.
HOWEVER, LIKE MOST ORGANIC COMPOUNDS IT IS COMBUSTIBLE AND MAY FORM
A DUST EXPLOSION IF WIDELY DIS PERSED IN AIR.

Spill Release Procedures:FLOOR SWEEPING IS NOT PERMITTED FOR CLEANING
POWDERS. CAREFULLY VACUUM UP SPILL USING A HEPA FILTERED VACUUM,
PRIOR TO WET MOPPING/CLEANING. MINIMIZE CONTACT WITH SPILLED
MATERIAL. KEEP OTHER PERSONNE L AWAY FROM THE CLEAN UP AREA. WEAR
APPROPRIATE RESPIRATORY PROTECTION AND PROTECTIVE CLOTHING IN THE
SPILL AREA AS SPECIFIED IN (EXPOSURE CONTROLS) SECTION. NOTIFY YOUR
SUPERVISOR (STATE REGULATORY)

Handling and Storage Precautions:HANDLING PRECAUTIONS: OPEN HANDLING IS
LIMITED TO SMALL QUANTITIES. FUME HOODS AND OTHER OPEN-FACE
CONTAINMENT DEVICES ARE ACCEPTABLE WHEN FACE VELOCITIES OF AT LEAST
80 FPM ARE ACHIEVED. PARTITIONS, BARRIERS, AND OTHER PARTIAL
CONTAINMENT TECHNOLOGIES ARE REQUIRED TO PREVENT (OTHER
PRECAUTIONS)
Other Precautions:HANDLING & STORAGE PRECAUTIONS (CONT): OF THE
COMPOUND TO UNCONTROLLED AREAS. STORAGE PRECAUTIONS: STORE IN
DOUBLE LINED PLASTIC IN FIBREBOARD OR OTHER APPROPRIATE CONTAINER.
IT IS SUGGESTED THAT A DOUBLE BAGGING SYSTEM BE USED TO MINIMIZE
EXPOSURE. KEEP CONTAINER TIGHTLY CLOSED IN A COOL WELL
VENTILATED PLACE.

Respiratory Protection:(NIOSH APPROVED - ) POWERED AIR PURIFYING
RESPIRATOR WITH HEPA CARTRIDGES, OR POSITIVE PRESSURE FULL FACE AIR
SUPPLIED RESPIRATOR.
Ventilation:A MINIMUM OF 10 AIR CHANGES PER HOUR IS RECOMMENDED.
AIR-RECIRCULATION MAY BE PERMITTED IN LIMITED SITUATIONS. AIR FLOW
MUST BE DIRECTED AWAY FROM (SARA III)
Protective Gloves:LATEX. DOUBLE GLOVING IS SUGGESTED.
Eye Protection:(ANSI APPROVED - ) SAFETY GOGGLES OR FULL FACE
RESPIRATORY PROTECTION.
Other Protective Equipment:SINGLE USE TYVEK PROTECTIVE CLOTHING.
EYEWASH AND DELUGE SHOWER MEETING ANSI DESIGN CRITERIA .
Work Hygienic Practices:CONTROLLED ACCESS TO THE WORK AREA IS
RECOMMENDED. ONLY THOSE PERSONS WHO HAVE RECEIVED TRAINING SPECIFIC
TO THE COMPOUND SHOULD BE ADMITTED. WORK SURFACES AND EQUIPMENT
(SUPPLEMENTAL SAFETY & HEALTH)
Supplemental Safety and Health
WORK HYGENIC PRACTICES (CONT): SHOULD BE DECONTAMINATED AFTER ALL
POTENTIAL HIGH RISK ACTIVITIES. EATING, DRINKING, SMOKING, AND
APPLYING COSMETICS ARE NOT PERMITTED IN THE WORK AREA. USE
INDICATED PE RSONAL PROTECTIVE EQUIPMENT WHILE HANDLING. AVOID
EXPOSURE. OBTAIN SPECIAL INSTRUCTIONS BEFORE USE. DO NOT BREATHE
DUST

Boiling Pt:B.P. Text:N/A C
Melt/Freeze Pt:=166.C, 330.8F
M.P/F.P Text:MELTING POINT
pH:4.2 @ 100 G/L C
Solubility in Water:111 GM/LITER
Appearance and Odor:SOLID, WHITE CRYSTALLINE POWDER. ODOR: NONE
SPECIFIED BY MANUFACTURER .

Stability Indicator/Materials to Avoid:YES
OXIDIZING AGENTS.
Hazardous Decomposition Products:CARBON MONOXIDE AND NOX.

Waste Disposal Methods:MATERIAL SHOULD BE DISPOSED IN AN
ENVIRONMENTALLY SOUND MANNER (I.A.W APPLICABLE REGULATIONS - FPN).
INCINERATION IS THE PREFERRED DISPOSAL METHOD. ALL WASTE MATERIAL
SHOULD BE DOUBLE BAGGED AND PLAC ED IN A CLEARLY LABELED RIDGID
CONTAINER ACCORDING TO LOCAL APPLICABLE STANDARDS. MATERIAL SHOULD
NO T BE CRUSHED OR SHREDDED PRIOR TO FINAL DISPOSAL.

Toxicological Information:SIGNS & SYMPTOMS OF OVEREXPOSURE (CONT):
HEMOLYSIS OF ERYTHROCYTES AND INHIBITION OF LATE STAGES OF
ERYTHROCYTE DEVELOPMENT IN BONE MARROW. TERATOGENIC (BIRTH
DEFECTS): RIBAVIRIN HAS BEEN SHOWN TO B E TERATOGENIC IN ALMOST ALL
ANIMAL SPECIES TESTED TO DATE. REPRODUCTIVE EFFECTS: MAY CAUSE
FETAL TOXICITY. TOXIC TO LACTATING ANIMALS AND THEIR OFFSPRING.
RIBAVIRIN CAUSED TESTICULAR ATROPHY IN MIC E AT A LOW DOSE RATE OF
16 MG/KG/DAY; THIS EFFECT WAS REVERSIBLE UNDER CESSATION OF
EXPOSURE. MUTAGENICITY: THE MUTAGENICITY OF RIBAVIRIN IN ANIMALS
IS QUESTIONABLE. IN BALB / 3T3 TRANSFORMATION ASS AY, THERE WAS
(ECOLOGICAL INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:ECOLOGICAL EFFECTS OR OTHER ECOLOGICALLY DAMAGING PROFILE
ARE UNKNOWN. BACTERIA TOXICITY: EC50 GREATER THAN OR EQUAL TO
10,000 MG/L (VIRBRIO) TOD 1187 MG 02/GRAM. TOXICOLOGICAL INFO
(CONT): INC REASED TRANSFORMATIONS AT THE HIGHEST DOSE. THERE WAS
NO EVIDENCE OF DOSE RESPONSE. IN THE MOUSE LYMPHOMA ASSAY,
RIBAVIRIN PRODUCED A DOSE-RELATED INCREASE IN MUTANT FREQUENCIES.
IN A DOMINANT LETHAL ASSAY, RIBAVIRIN DID NOT INDUCE EFFECTS
EXPRESSED AS DOMINANT LETHALITY WHEN MALE MALE RATS WERE EXPOSED
TO MAXIMUM TOLERATED DOSES. MISCELLANEOUS TOXICOLOGICAL
INFORMATION: ACUTE TOXICITY DATA: LD5 0 RAT ORAL: 5300 MG/KG.
(TRANSPORT INFO)

Transport Information:PROPER SHIPPING NAME: NOT CLASSIFIED FOR
TRANSPORT. ECOLOGICAL INFO (CONT): LD50 MOUSE,
INTRAPERITONEAL: 1300 MG/KG. TDLO RAT, ORAL: 25 MG/KG; TDLO
HAMSTER: 2500 UG/KG. RIBAVIRIN HAS SHOWN TERA TOGENIC EFFECTS IN
MULTIPLE ANIMAL SPECIES. THIS DATA SUGGESTS A SIGNIFICANT RISK OF
TERATOGENICITY IN HUMANS. EXPERIENCE IN HUMANS: HEADACHE AND PAIN
IN THE EYES ON CONTACT; SKIN IRRITATION. EXPOSU RE LIMITS:
SHERING OEG: 5 MCG/M3. SURFACE LEVEL: 50 MCG/ 100 CM2.

SARA Title III Information:N/P. VENTILATION (CONT): THE
OPERATOR'S BREATHING ZONE. AIR PRESSURE SHOULD BE NEGATIVETO
SURROUNDING AREAS. LOCAL EXHAUST VENTILATION MUST BE PROVIDED AT
THE SOURCES OF CONTAMINATION. SURFAC ES SHOULD BE SMOOTH,
NON-POROUS, WITH MINIMAL LEDGES AND EASILY CLEANED.
Federal Regulatory Information:EUROPEAN (ECC) REGULATORY INFORMATION:
LABELING INFORMATION: HEALTH HARMFUL SYMBOL "XN". R PHRASES:
R39/23/24/25: SERIOUS DANGER OF IRREVERSIBLE DANGER IF INHALED,
AFTER CONTACT WITH SKIN, IF SWALLOWE D. R62: MAY CAUSE HARM TO
UNBORN CHILD. R63: POSSIBLE RISK OF IMPAIRED FERTILITY. S PHRASES:
S1: KEEP LOCKED UP. S13: KEEP AWAY FROM FOOD, DRINK AND ANIMAL
FEED. S20/21: DO NOT EAT, DRINK OR SMOKE WHI LE WORKING. S36/37/39:
WEAR SUITABLE PROTECTIVE CLOTHING, PROTECTIVE GLOVES, PROTECTIVE
GOGGLES/FAC E PROTECTION WHILE WORKING. S3/7: KEEP CONTAINER
TIGHTLY CLOSED AND STORE IN A COOL PLACE.
State Regulatory Information:N/P. SPILL RELEASE PROCEDURES
(CONT): IMMEDIATELY. DISPOSE OF SPILLED MATERIAL AND CLEAN UP
MATERIALS AS NOTED IN (WASTE DISPOSAL) SECTION.