Product ID:4456 ULTANE SEVOFLURANE
MSDS Date:05/18/1996
FSC:NIIN:Submitter:F BT
Status Code:A
MSDS Number: CJFYL

Emergency Phone: 1-847-937-7970

Info Phone: 708-937-6100

Cage: 60060

Telephone: 847-935-7177

Cage: 60060

SEVOFLURANE

CAS: 28523-86-6

RTECS: KO0737000

Routes of Entry: Inhalation:YES Skin:UNKNOWN Ingestion:NO
Health Hazards Acute and Chronic:THIS MATERIAL IS USED TO PRODUCE
ANESTHESIA (SLEEP). TARGET ORGANS INCLUDE THE CENTRAL NERVOUS
SYSTEM, RESPIRATORY SYSTEM, CARDIOVASCULAR SYSTEM & POSSIBLY THE
FETUS.
Effects of Overexposure:SEVOFLURANE PRODUCES ANESTHESIA W/SYMPTOMS OF:
RESPIRATORY DEPRESSION, HYPOTENSION, BRADYCARDIA, SHIVERING,
NAUSEA, HEADACHE.
Medical Cond Aggravated by Exposure:PATIENTS SENSITIVE TO HALOGENATED
ANESTHETICS; CARDIOVASCULAR/RESPIRATORY DISEASES.

First Aid:EYES/SKIN/INGESTION/INHALATION: REMOVE FROM SOURCE OF
EXPOSURE. FLUSH SKIN & EYES W/COPIOUS AMOUNTS OF WATER. PROVIDE
SYMPTOMATIC/SUPPORTIVE CARE, MAINTAINING VENTILATION W/PURE OXYGEN
AS NECESSARY.

Extinguishing Media:WATER SPRAY, CO2/DRY CHEMICAL POWDER
Fire Fighting Procedures:WEAR SELF CONTAINED BREATHING APPARATUS.
Unusual Fire/Explosion Hazard:AVOID INHALATION OF COMBUSTION PRODUCTS.

Spill Release Procedures:VENTILATE AREA & WASH SITE AFTER MATERIAL WIPE
UP IS COMPLETE. COLLECT AS POISONOUS ORGANIC CHEMICAL, PLACE IN
CONTAINER & HOLD FOR WASTE DISPOSAL.

Handling and Storage Precautions:STORE AT CONTROLLED ROOM TEMPERATURE
OF 59-86F. KEEP CONTAINERS CLOSED & AWAY FROM LIGHT.

Respiratory Protection:IF ENGINEERING CONTROLS ARE IN PLACE,
RESPIRATORS ARE GENERALLY NOT REQUIRED. ENTRY INTO AREAS OF UNKNOWN
AIRBORNE CONCENTRATION OF THIS PRODUCT SHOULD ONLY BE MADE W/A SELF
CONTAINED BREATHING APPARA TUS.
Ventilation:IN THE LABORATORY ENVIRONMENT, THIS PRODUCT SHOULD BE
HANDLED IN A HOOD.
Protective Gloves:IMPERIVOUS
Eye Protection:UNDER NORMAL USE CONDITIONS, NO PROTECTION IS
ANTICIPATED.
Supplemental Safety and Health

Boiling Pt:=58.5C, 137.5F
Vapor Pres:245.5
Vapor Density:6.94
Spec Gravity:1.525
pH:7-7.5
Evaporation Rate & Reference:HIGHLY VOLATILE
Solubility in Water:0.01%
Appearance and Odor:CLEAR, COLORLESS LIQUID

Stability Indicator/Materials to Avoid:YES
ALKALINE EARTH METALS, STRONG BASES
Hazardous Decomposition Products:CO, CO2, HYDROGEN FLUORIDE

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/LOCAL, STATE &
FEDERAL REGULATIONS.

Toxicological Information:SPECIAL TARGET ORGAN EFFECTS: CLINICALLY,
SEVOFLURANE PRODUCES ANESTHESIA W/A MINIMUM ALVEOLAR CONCENTRATION
OF 20,000 PPM. A SMALL AMOUNT OF AN INSPIRED DOSE IS METABOLIZED TO
FLUORIDE & A FLUORIDE C ONTAINING METABOLITE. LARGE CONCENTRATIONS
OF SEVOFLURANE HAVE PRODUCED SLIGHT ELEVATIONS IN SERUM ENZYMES &
PRODUCED MATERNAL EFFECTS, FETAL EFFECTS (DECREASED WEIGHT GAINS),
CLEFT PALATE & DECREASED REPRODUCTIVE PERFORMANCE IN ANIMAL
STUDIES.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.